Mesenchymal Stem Cells For Cellular Therapies

  • Catarina Madeira
  • Francisco dos Santos
  • Pedro Z. Andrade
  • Cláudia Lobato da Silva
  • Joaquim M.S. Cabral
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 3)


In the last decade, an increasing number of studies led to a more in-depth knowledge of the immunomodulatory, engraftment-promoting and regenerative properties of mesenchymal stem cells (MSC). Research on MSC clinical applications has been intensified in the last few years and, as a consequence, in early 2011 there were already 165 registered clinical trials with MSC. On the other hand, some relevant pre-clinical studies have shown promising results in terms of efficiency and safety when using MSC overexpressing therapeutic proteins. Although the merging of both gene and stem cell therapy still remain in a pre-clinical stage, in few years this innovative therapy will certainly be exploited in clinical trials and ultimately established as current medical practice. Indeed, the extraordinary features of MSC has widen the number of MSC based clinical therapies, eventually anticipating palliative procedures instead of current aggressive therapies, or even the cure of untreatable diseases.


Graft versus host disease GSK-3β DNA FDA EMA VEGF 


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Catarina Madeira
    • 1
  • Francisco dos Santos
    • 1
  • Pedro Z. Andrade
    • 1
  • Cláudia Lobato da Silva
    • 1
  • Joaquim M.S. Cabral
    • 2
  1. 1.Department of BioengineeringInstituto Superior Técnico (IST)LisboaPortugal
  2. 2.Department of BioengineeringInstitute for Biotechnology and Bioengineering (IBB), Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Technical University of LisbonLisboaPortugal

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