Oxidative DNA Damage Mediated by Transition Metal Ions and Their Complexes

  • Geneviève PratvielEmail author
Part of the Metal Ions in Life Sciences book series (MILS, volume 10)


DNA damage by redox-active metal complexes depends on the interaction of the metal complex with DNA together with the mechanism of oxygen activation. Weak interaction, tight binding, and direct involvement of DNA in the coordination sphere of the metal are described. Metal complexes acting through the production of diffusing radicals and metal complexes oxidizing DNA by metal-centered active species are compared. Metal complexes able to form high-valent metal-oxo species in close contact with DNA and perform DNA oxidation in a way reminiscent of enzymatic chemistry are the most elegant systems.


DNA-metal interaction hydroxyl radical iron bleomycin manganese porphyrin nickel complexes platinum complexes 



The contribution of coauthors whose names appear in the references is acknowledged. This article is dedicated to Dr Marguerite Pitié.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Laboratoire de Chimie de CoordinationCNRSToulouse-Cedex 04France

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