G-Quadruplexes and Metal Ions

  • Nancy H. Campbell
  • Stephen NeidleEmail author
Part of the Metal Ions in Life Sciences book series (MILS, volume 10)


Metal ions stabilize quadruplex nucleic acids by coordinating the O6 guanine atoms from G-quartets. These quartets form the basic motif of quadruplex structures. This article systematically surveys the available crystallographic data on native quadruplexes, their ligand complexes and (in one instance) a protein complex. Three categories of quadruplex are examined, tetramolecular, bimolecular, and intramolecular: all are formed by telomeric nucleic acid sequences from human or ciliate organisms.


crystal structures ion channel metal ion coordination Protein Data Bank quadruplex 



This work was supported by a CRUK Programme Grant to S. Neidle.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.CRUK Biomolecular Structure Group, The School of PharmacyUniversity of LondonLondonUK

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