Neurogenesis in the Cerebral Cortex After Stroke

  • Yukiko Kasahara
  • Takayuki Nakagomi
  • Tomohiro Matsuyama
  • Akihiko TaguchiEmail author
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 2)


In the adult mammalian brain, new neurons are continuously generated at the subventricular zone of the lateral ventricles and the subgranular zone of the hippocampal dentate gyrus. In the cerebral cortex, though the generation of new neurons is rarely observed in physiological situations, induction of neurogenesis has been shown under pathological conditions, such as after cerebral ischemia. In this chapter, we introduce the injury-induced neural stem/progenitor cells in the cerebral cortex and its potential for functional recovery. We also refer to the therapeutic potential of exogenous neuronal stem cell transplantation and discuss the future of cell-based therapy for stroke patients.


Central nervous system Neurogenesis Cerebral cortex Cerebral infarction Neural stem cells 


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Yukiko Kasahara
    • 1
  • Takayuki Nakagomi
    • 2
  • Tomohiro Matsuyama
    • 2
  • Akihiko Taguchi
    • 1
    Email author
  1. 1.Department of Cerebrovascular DiseaseNational Cardiovascular CenterSuita, OsakaJapan
  2. 2.Institute for Advanced Medical Sciences, Hyogo College of MedicineHyogoJapan

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