Garcinia gummi-gutta

  • T. K. Lim
Chapter

Abstract

Cambogia gummi-guta L., Cambogia gutta L., Cambogia gutta Lindl., Garcinia affinis Wight & Arn., Garcinia cambogia (Gaertn.) Desr. nom. illeg., Garcinia conicarpa Wight, Garcinia gummi-gutta var. conicarpa (Wight) N. P. Singh, Garcinia elliptica Wall., Garcinia papilla Wight, Garcinia quaesita Pierre, Garcinia zeylanica Roxb.,

Selected References

  1. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF (2007) Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem 304(1–2):93–99Google Scholar
  2. Chattopadhyay SK, Kumar S (2007) Liquid chromatography-tandem mass spectrometry method for identification and quantification of two biologically active polyisoprenylated benzophenones, isoxanthochymol and camboginol, in Garcinia species. Biomed Chromatogr 21(11):1159–1165Google Scholar
  3. Council of Scientific and Industrial Research (CSIR) (1956) The wealth of India. A dictionary of Indian raw materials and industrial products. (Raw materials 4). Publications and Information Directorate, New DelhiGoogle Scholar
  4. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D (2008a) Safety of a novel calcium/potassium salt of hydroxycitric acid (HCA-SX): I. two-generation reproduction toxicity study. Toxicol Mech Methods 18(5):433–442Google Scholar
  5. Deshmukh NS, Bagchi M, Yasmin T, Bagchi D (2008b) Safety of a novel calcium/potassium saltof (−)-hydroxycitric acid (HCA-SX): II. Developmental toxicity study in rats. Toxicol Mech Methods 18(5):443–451Google Scholar
  6. dos Reis SB, de Oliveira CC, Acedo SC, Miranda DD, Ribeiro ML, Pedrazzoli J Jr, Gambero A (2009) Attenuation of colitis injury in rats using Garcinia cambogia extract. Phytother Res 23(3):324–329Google Scholar
  7. Foundation for Revitalisation of Local Health Traditions (2008) FRLHT database. htttp://envis.frlht.org
  8. Gamble JS (1915) Flora of the presidency of Madras, vol 1. West, Newman and Adlard, LondonGoogle Scholar
  9. Geetha CK (1994) Kodampuli – Garcinia cambogia – an underexploited crop in the Kerala homestead. Spice India 7(4):9–10Google Scholar
  10. Hasegawa N (2001) Garcinia extract inhibits lipid droplet accumulation without affecting adipose conversion in 3T3-L1 cells. Phytother Res 15(2):172–173Google Scholar
  11. Hayamizu K, Hirakawa H, Oikawa D, Nakanishi T, Takagi T, Tachibana T, Furuse M (2003) Effect of Garcinia cambogia extract on serum leptin and insulin in mice. Fitoterapia 74(3):267–273Google Scholar
  12. Hayamizu K, Tomi H, Kaneko I, Shen M, Soni MG, Yoshino G (2008) Effects of Garcinia cambogia extract on serum sex hormones in overweight subjects. Fitoterapia 79(4):255–261Google Scholar
  13. Heymsfield SB, Allison DB, Vasselli JR, Pietrobelli A, Greenfield D, Nunez C (1998) Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA 280(18):1596–1600Google Scholar
  14. Hooker JD (1875) Flora of British India, vol 1. L. Reeve, London, pp 261–262Google Scholar
  15. Ishihara K, Oyaizu S, Onuki K, Lim K, Fushiki T (2000) Chronic (−)-hydroxycitrate administration spares carbohydrate utilization and promotes lipid oxidation during exercise in mice. J Nutr 130(12):2990–2995Google Scholar
  16. Jayaprakasha GK, Sakariah KK (1998) Determination of organic acids in Garcinia cambogia (Desr.) by high-performance liquid chromatography. J Chromatogr A 806(2):337–339Google Scholar
  17. Jayaprakasha GK, Sakariah KK (2000) Determination of (−) hydroxycitric acid in commercial samples of Garcinia cambogia extract by liquid chromatography with ultraviolet detection. J Liq Chromatogr Relat Technol 23(6):915–923Google Scholar
  18. Jena BS, Jayaprakasha GK, Singh RP, Sakariah KK (2002) Chemistry and biochemistry of (−)-hydroxycitric acid from Garcinia. J Agric Food Chem 50(1):10–22Google Scholar
  19. Kim KY, Lee HN, Kim YJ, Park T (2008a) Garcinia cambogia extract ameliorates visceral adiposity in C57BL/6J mice fed on a high-fat diet. Biosci Biotechnol Biochem 72(7):1772–1780Google Scholar
  20. Kim YJ, Kim KY, Kim MS, Lee JH, Lee KP, Park TS (2008b) A mixture of the aqueous extract of Garcinia cambogia, soy peptide and l-carnitine reduces the accumulation of visceral fat mass in rats rendered obese by a high fat diet. Genes Nutr 2(4):353–358Google Scholar
  21. Kolodziejczyk J, Masullo M, Olas B, Piacente S, Wachowicz B (2009) Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative/nitrative modifications in blood platelets and plasma. Platelets 20(7):487–492Google Scholar
  22. Koshy AS, Vijayalakshmi NR (2001) Impact of certain flavonoids on lipid profiles – potential action of Garcinia cambogia flavonoids. Phytother Res 15(5):395–400Google Scholar
  23. Kostermans AJGH (1980) Clusiaceae (Guttiferae). In: Dassanayake MD (ed) A revised handbook to the flora of Ceylon, vol 1. Amerind Publishing Company, Private Ltd., New Delhi, pp 72–89Google Scholar
  24. Lee KH, Lee BM (2007) Evaluation of the genotoxicity of (−)-hydroxycitric acid (HCA-SX) isolated from Garcinia cambogia. J Toxicol Environ Health A 70(5):388–392Google Scholar
  25. Mahendran P, Shyamala Devi CS (2001a) Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian J Physiol Pharmacol 45(3):345–350Google Scholar
  26. Mahendran P, Shyamala Devi CS (2001b) Modulating effect of Garcinia cambogia extract on ethanol induced peroxidative damage in rats. Indian J Pharmacol 33(2):87–91Google Scholar
  27. Mahendran P, Sabitha KE, Shyamala Devi CS (2002) Prevention of HCl-ethanol induced gastric mucosal injury in rats by Garcinia cambogia extract and its possible mechanism of action. Indian J Exp Biol 40:58–62Google Scholar
  28. Maheshwari JK (1965) Taxonomic studies on Indian Guttiferae. III. The genus Garcinia Linn. Sensu lato. Bull Bot Surv India 6:128–129Google Scholar
  29. Manomohandas TP, Anith KN, Gopakumar S, Jayaranja M (2001) Kodampuli – a fruit for all reasons. Agroforest Today 13(1–2):7–8Google Scholar
  30. Masullo M, Bassarello C, Suzuki H, Pizza C, Piacente S (2008) Polyisoprenylated benzophenones and an unusual polyisoprenylated tetracyclic xanthone from the fruits of Garcinia cambogia. J Agric Food Chem 56(13):5205–5210Google Scholar
  31. Mattes RD, Bormann L (2000) Effects of (−)-hydroxycitric acid on appetitive variables. Physiol Behav 71(1–2):87–94Google Scholar
  32. McCarty MF (1994) Promotion of hepatic lipid oxidation and gluconeogenesis as a strategy for appetite control. Med Hypotheses 42:215–225Google Scholar
  33. McCarty MF (1995a) Inhibition of citrate lyase may aid aerobic endurance. Med Hypotheses 45:247–254Google Scholar
  34. McCarty MF (1995b) Optimizing exercise for fat loss. Med Hypotheses 44:325–330Google Scholar
  35. Ohia SE, Awe SO, LeDay AM, Opere CA, Bagchi D (2001) Effect of hydroxycitric acid on serotonin release from isolated rat brain cortex. Res Commun Mol Pathol Pharmacol 109(3–4):210–216Google Scholar
  36. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ (2002) Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem 238:89–103Google Scholar
  37. Oikawa D, Hirakawa H, Hayamizu K, Nakamura Y, Shiba N, Nakanishi T, Iwamoto H, Tachibana T, Furuse M (2005) Dietary Garcinia cambogia does not modify skin properties of mice with or without excessive sucrose intake. Phytother Res 19(4):294–297Google Scholar
  38. Oluyemi KA, Omotuyi IO, Jimoh OR, Adesanya OA, Saalu CL, Josiah SJ (2007) Erythropoietic and anti-obesity effects of Garcinia cambogia (bitter kola) in Wistar rats. Biotechnol Appl Biochem 46(Pt 1):69–72Google Scholar
  39. Porcher MH et al (1995–2020) Searchable world wide web multilingual multiscript plant name database. The University of Melbourne, Australia. http://www.plantnames.unimelb.edu.au/Sorting/Frontpage.html
  40. Preuss HG, Rao CV, Garis R, Bramble JD, Ohia SE, Bagchi M, Bagchi D (2004) An overview of the safety and efficacy of a novel, natural (−)-hydroxycitric acid extract (HCA-SX) for weight management. J Med 35(1–6):33–48Google Scholar
  41. Roy S, Rink C, Khanna S, Phillips C, Bagchi D, Bagchi M, Sen CK (2004) Body weight and abdominal fat gene expression profile in response to a novel hydroxycitric acid-based dietary supplement. Gene Expr 11(5–6):251–262Google Scholar
  42. Saito M, Ueno M, Ogino S, Kubo K, Nagata J, Takeuchi M (2005) High dose of Garcinia cambogia is effective in suppressing fat accumulation in developing male Zucker obese rats, but highly toxic to the testis. Food Chem Toxicol 43(3):411–419Google Scholar
  43. Shara M, Ohia SE, Schmidt RE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi M, Chatterjee A, Bagchi D, Stohs SJ (2004) Physico-chemical properties of a novel (−)-hydroxycitric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Mol Cell Biochem 260(1–2):171–186Google Scholar
  44. Shara M, Ohia SE, Yasmin T, Zardetto-Smith A, Kincaid A, Bagchi M, Chatterjee A, Bagchi D, Stohs SJ (2003) Dose- and time-dependent effects of a novel (−)-hydroxycitric acid extract on body weight, hepatic and testicular lipid peroxidation, DNA fragmentation and histopathological data over a period of 90 days. Mol Cell Biochem 254(1–2):339–346Google Scholar
  45. Sullivan AC, Triscari J, Hamilton JG, Miller ON (1974) Effect of (−)-hydroxycitrate upon the accumulation of lipid in the rat. II. Appetite. Lipids 9:129–134Google Scholar
  46. Sullivan AC, Triscari J, Spiegel JE (1977) Metabolic regulation as a control for lipid disorders. II. Influence of (−)-hydroxycitrate on genetically and experimentally induced hypertriglyceridemia in the rat. Am J Clin Nutr 30:777–784Google Scholar
  47. Szutowicz A, Stepien M, Lysiak W, Angielski S (1976) Effect of (−) hydroxycitrate on the activities of ATP citrate lyase and the enzymes of acetyl-CoA metabolism in rat brain. Acta Biochim Pol 23:227–234Google Scholar
  48. van Loon LJC, van Rooijen JJM, Niesen B, Verhagen H, Saris WHM, Wagenmakers AJM (2000) Effects of acute (−)-hydroxycitrate supplementation on substrate metabolism at rest and during exercise in humans. Am J Clin Nutr 72(6):1445–1450Google Scholar
  49. Vasques CA, Rossetto S, Halmenschlager G, Linden R, Heckler E, Fernandez MS, Alonso JL (2008) Evaluation of the pharmacotherapeutic efficacy of Garcinia cambogia plus Amorphophallus konjac for the treatment of obesity. Phytother Res 22(9):1135–1140Google Scholar
  50. Yamada T, Hida H, Yamada Y (2007) Chemistry, physiological properties, and microbial production of hydroxycitric acid. Appl Microbiol Biotechnol 75(5):977–982Google Scholar
  51. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T (2008) Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr 42(2):89–103Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • T. K. Lim
    • 1
  1. 1.ChisholmAustralia

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