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Stem Cells Like Astrocytes: Various Roles

  • Florian A. SiebzehnrublEmail author
  • Dennis A. Steindler
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 1)

Abstract

Adult stem cells have been identified in the brain, and continue to generate new neurons throughout life. These stem cells share a number of features with astrocytes, and recent evidence points to certain types of astrocytes capable of acquiring a stem-like phenotype. Stem cells have been implied as a potential origin for malignant glioma, especially glioblastoma multiforme (GBM), but are also known to react to a tumour by increased proliferation and migration towards the tumour mass. This apparent dichotomy between root and counteraction is discussed in this chapter, as well as the possibility of employing endogenous stem cells for brain cancer therapy.

Keywords

Stem cells Astrocytes Tumor Brain Neurons NSC 

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Florian A. Siebzehnrubl
    • 1
    Email author
  • Dennis A. Steindler
    • 2
  1. 1.Department of NeurosurgeryThe Evelyn F. and William L. McKnight Brain Institute, University of FloridaGainesvilleUSA
  2. 2.Department of NeurosurgeryThe Evelyn F. and William L. McKnight Brain Institute, University of FloridaGainesvilleUSA

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