Engineered Nanostructures for the Ultrasensitive DNA Detection

  • Dong-Kwon Lim
  • Amit Kumar
  • Jwa-Min NamEmail author
Part of the Soft and Biological Matter book series (SOBIMA)


Coupled with nanotechnologies, a wide variety of DNA sensing methods have been developed to achieve ultrahigh sensitivity and selectivity without the aid of enzymatic amplification procedures or complicated assay procedures. Structurally engineered nanomaterials have several useful aspects including their unique optical properties depending on size, shape, composition and structural details and electrical properties, which have been translated into various signal transduction modes. However, the most important challenge in DNA detection assay to compete with or complement the polymerase chain reaction (PCR) is matching the sensitivity of PCR, which can detect 10–100 copies in whole sample via various non-enzymatic amplification strategies. Here, we introduce recent advances in engineered nanostructure-based DNA detection methods that show potential for PCR-like sensitivity and can address the existing issues of conventional DNA detection assays. The basic principles, advantages, and limitations of engineered nanostructure-amplified DNA detection methods will be introduced and discussed.


Silver Nanoparticles Surface Plasmon Resonance Gold Nanoparticles Surface Enhance Raman Scattering West Nile Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Department of ChemistrySeoul National UniversitySeoulSouth Korea

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