The Informatics of High-Throughput Mouse Phenotyping: EUMODIC and Beyond
Now that not only the mouse genome sequence but also the ability to carry out high throughput manipulation of mouse ES cells is in place, projects are underway to understand the functions of individual mouse genes in a systematic manner. Central to this will be the systematic analysis of the phenotypes of mutant mouse lines. EUMODIC, the first large-scale project to screen mouse knockout lines for disease-related phenotypes is underway and experience shows the necessity of a well-organised bioinformatics infrastructure for the capture, analysis and dissemination of the data emerging from such projects. Here we discuss the fundamental requirements for such a bioinformatics infrastructure, progress so far and the developments that will be required in future.
KeywordsPhenotype Data Laboratory Information Management System Mammalian Phenotype Open Source Software Project Phenotyping Centre
We thank the many contributors to the development of the ideas described here including the developers of the Mouse Genome Database, Mouse Phenome Database and the partners in EUMORPHIA and EUMODIC. We thank the UK Medical Research Council and the European Commission for financial support. EUMORPHIA and EUMODIC were funded by the European Commission under contract numbers QLG2-CT-2002-00930 and LSHG-CT-2006-037188.
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