Molecular Targets of Resveratrol in Carcinogenesis

Chapter
Part of the Evidence-based Anticancer Complementary and Alternative Medicine book series (ACAM)

Abstract

Resveratrol, a dietary phytoalexin readily available in the diet, is reported to possess antitumorigenic and anti-inflammation activity in several cancers. However, the molecular mechanisms and/or targets underlying the antitumorigenic activity of this compound remain largely unknown. As a potential signaling pathway modulator, resveratrol is shown to affect a multitude of signaling transduction pathways, and it is likely that this collective activity may play an important role in resveratrol-induced antitumorigenesis. Therefore, the elucidation of molecular targets of resveratrol is necessary to understand how this compound is beneficial in antitumorigenic processes. Studies to identify molecular markers have recently spawned increasing examination of the possible targets of resveratrol as related to anticancer proteins. These include, but are not limited to: (1) inhibition of carcinogenic activation and induction of detoxification by Phase I and Phase II xenobiotic metabolizing enzymes, respectively, (2) modulation of cell survival and apoptosis, (3) suppression of pro-inflammatory signaling pathways, (4) inhibition of angiogenesis, invasion, and metastasis, and (5) modulation of hormonal receptors. This chapter summarizes the diverse molecular targets of resveratrol in prevention and treatment of carcinogenesis.

Keywords

Dextran Sodium Sulfate Aryl Hydrocarbon Receptor Cigarette Smoke Extract Endometrial Cancer Cell Resveratrol Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Department of Pathobiology, College of Veterinary MedicineUniversity of TennesseeKnoxvilleUSA
  2. 2.Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary MedicineUniversity of TennesseeKnoxvilleUSA

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