Evolvability and Self-Replication of Genetic Information in Liposomes
To realize the minimal cell by a bottom-up approach, increasingly complex biochemical reactions are being encapsulated in lipid vesicles (liposomes). Here, we describe the encapsulation of one of the general properties of living organisms into liposomes, i.e., replication of genetic information with self-encoded replicase, and evolvability. We also discuss the possibility of realizing a minimal cell that can proliferate autonomously.
KeywordsBottom-up approach Constructive approach Lipid vesicles Self-encoding system Evolvability Qβ replicase
This research was supported in part by “Special Coordination Funds for Promoting Science and Technology: Yuragi Project” and “Global COE (Centers of Excellence) Program” of the Ministry of Education, Culture, Sports, Science, and Technology, Japan.
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