Evolvability and Self-Replication of Genetic Information in Liposomes

  • Tomoaki Matsuura
  • Norikazu Ichihashi
  • Takeshi Sunami
  • Hiroshi Kita
  • Hiroaki Suzuki
  • Tetsuya YomoEmail author


To realize the minimal cell by a bottom-up approach, increasingly ­complex biochemical reactions are being encapsulated in lipid vesicles (liposomes). Here, we describe the encapsulation of one of the general properties of living organisms into liposomes, i.e., replication of genetic information with self-encoded replicase, and evolvability. We also discuss the possibility of realizing a minimal cell that can ­proliferate autonomously.


Bottom-up approach Constructive approach Lipid vesicles Self-encoding system Evolvability Qβ replicase 



This research was supported in part by “Special Coordination Funds for Promoting Science and Technology: Yuragi Project” and “Global COE (Centers of Excellence) Program” of the Ministry of Education, Culture, Sports, Science, and Technology, Japan.


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Copyright information

© Springer Netherlands 2011

Authors and Affiliations

  • Tomoaki Matsuura
    • 2
    • 3
  • Norikazu Ichihashi
    • 2
    • 3
  • Takeshi Sunami
    • 3
  • Hiroshi Kita
    • 3
  • Hiroaki Suzuki
    • 2
    • 3
  • Tetsuya Yomo
    • 1
    • 2
    • 3
    Email author
  1. 1.Graduate School of Frontier BiosciencesOsaka UniversitySuitaJapan
  2. 2.Department of Bioinformatics Engineering, Graduate School of Information Science and TechnologyOsaka UniversitySuitaJapan
  3. 3.Exploratory Research for Advanced Technology (ERATO), Japan Science and Technology Agency (JST)SuitaJapan

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