The Role of Tomato Lycopene in Cancer Prevention
The role of the tomato carotenoid lycopene in cancer prevention has gained considerable interest in recent years. Most studies reported an inverse association between tomato intake or blood lycopene level and the risk of various types of cancer. This is supported by mechanistic studies with various cell culture and animal models. The biochemical processes involved in the chemoprotective effects of lycopene and other carotenoids are not completely understood. In this review we will primarily address the mechanisms proposed for the cancer preventive activity of tomato lycopene, focusing on the induction of phase II enzymes and the inhibition of growth factors, such as insulin-like growth factor, and sex hormones such as estrogens and androgens.
KeywordsTomato lycopene Phase II enzymes Growth factors Sex hormones Chemoprevention
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