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Types of Human Disease by Source of the Infectious Agent

  • Zdenek HubálekEmail author
  • Ivo Rudolf
Chapter

Abstract

In general, the source of infection for human beings is another human, or an animal, or the environment (extra-animal substrate). In line with this we can distinguish human infectious diseases as anthroponoses, zoonoses and sapronoses, respectively.

Keywords

Herpes Zoster Neisseria Gonorrhoeae Bacillary Dysentery Scrub Typhus Bordetella Pertussis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
In general, the source of infection for human beings is another human, or an animal, or the environment (extra-animal substrate). In line with this we can distinguish human infectious diseases as anthroponoses, zoonoses and sapronoses, respectively. The names have been derived from the Greek “νόσος” (nosos) = disease; “ανθρόπος” (anthropos) = man; “ζωός” (zoos) = living (animal); “σαπρός” (sapros) = decayed.

Type of human disease

The source of infection (habitat of the agent)

Man-to-man transmission

Anthroponosis

Human

Common

Zoonosis

Animal

Uncommon or rare

Sapronosis

Abiotic substrate

Very rare

Anthroponoses are diseases transmissible only from man to man. Typical microbial anthroponoses are typhoid fever (typhus abdominalis, caused by Salmonella typhi), paratyphoid fever, shigellosis (bacillary dysentery, the agents are Shigella spp.), whooping cough (the agent is Bordetella pertussis), diphtheria (Corynebacterium diphtheriae), streptococcal diseases (tonsillitis, scarlet fever, erysipelas), syphilis (Treponema pallidum), yaws (Treponema pertenue), gonorrhoea (Neisseria gonorrhoeae), Haemophilus infections (including Brazilian purpuric fever), chancroid (ulcus molle, Haemophilus ducreyi), tuberculosis caused by Mycobacterium tuberculosis, leprosy, trachoma (inclusion conjunctivitis) and lymphogranuloma venereum (Chlamydia trachomatis), chlamydial pneumonia and cardiovascular disease, mycoplasmal pneumonia, peptic ulcer disease, pneumococcal pneumonia, invasive group A streptococcal infections, meningococcal disease, common cold, epidemic influenza (except for that caused by certain types of zoonotic orthomyxoviruses – avian, swine or equine), poliomyelitis, some types of viral hepatitis (A, B, C), epidemic viral gastroenteritis, rubella, measles (morbilli, rubeola), mumps (infectious parotitis), epidemic haemorrhagic conjunctivitis, infectious mononucleosis, cytomegalovirus infection, smallpox (variola), herpes simplex, chickenpox (herpes zoster, caused by varicella-zoster virus), AIDS, ringworm caused by Trichophyton rubrum, Epidermophyton floccosum and some other species of dermatophytes, candidosis, Pneumocystis pneumonia (caused by human genotypes of P. jirovecii), some microsporidial infections, cryptosporidiosis (human genotypes), giardiasis (human genotype), trichomoniasis, amoebiasis (amoebic dysenteria, Entamoeba histolytica), and several other human diseases.

Zoonoses are diseases transmissible from animal to man. The term was invented by Rudolf Virchow during his study of trichinellosis in 1855. In general, zoonoses are not transmissible by contact from the patient to other people, although there are notable exceptions with haemorrhagic fevers Lassa, Machupo, Ebola, Marburg, CCHF, or SARS, plague etc. The term used earlier for diseases transmissible from animals to man was “anthropo-zoonoses”. By analogy, a term “zoo-anthroponoses” was used for diseases transmissible the other way, from man to animals; however the number of the latter is limited (e.g., influenza, tuberculosis). Regrettably, many epidemiologists started to use these both terms in a reverse order (zooanthroponoses as diseases transmissible from animals to man), or promiscuously. The WHO therefore suggested using “zoonoses” as the official term, and that the two previous terms should no longer be used. According to an expert commission of WHO/FAO the definition of zoonoses reads as follows: “Zoonoses are diseases and infections which are naturally transmitted between vertebrate animals and man” (WHO Tech Rep Ser 169, 1959). This definition was confirmed also by the third and fourth report of this Commission (WHO Tech Rep Ser 378, 1967; WHO Tech Rep Ser 682, 1982).

The number of known zoonoses is growing steadily, at present exceeding 250, about 80 of which are common. From the zoonoses discovered in recent decades we can mention for instance Lyme borreliosis, anaplasmosis, HFRS and other haemorrhagic fevers Lassa, Marburg and Ebola, hantavirus pulmonary syndrome, SARS or Nipah fever. However (and luckily), only a limited number of zoonoses can cause extensive outbreaks – e.g., salmonellosis, Q fever, yellow fever, Japanese encephalitis, West Nile fever, chikungunya, RVF and American equine encephalomyelitides. Other zoonoses attract public (and media) attention due to their high lethality, sometimes associated with a high contagiosity for attending medical personnel (haemorrhagic fevers).

The transmission of zoonotic agents from animal to man can be realized either directly, or indirectly, via a vector (usually a haematophagous, i.e. blood-feeding member of the phyllum Arthropoda); in the latter case we can speak about obligate or facultative vector transmission (so-called “meta-zoonosis” according to WHO 1967).

Zoonoses can further be divided according to the habitat or ecosystem where their agents circulate as: (i) synanthropic, with an urban (anthroponotic, domestic) cycle where the source of human infection are most often domestic animal or synanthropic vertebrates bound to human dwellings; or (ii) exoanthropic, with a sylvatic (feral) cycle, and their reservoir is in the countryside outside human dwellings – in so-called natural foci. The first group of zoonoses forms, e.g., vesicular stomatitis, brucellosis, bovine tuberculosis, glanders, listeriosis, erysipeloid or ringworm caused by Trichophyton verrucosum and Microsporum canis. These diseases are transmissible usually percutaneously, aerogenically, alimentarily or per conjunctiva, and often present typical occupational diseases in farmers, butchers and veterinary doctors. The second group form classic diseases with natural focality in the sense of J. N. Pavlovsky, e.g. tick-borne encephalitis and other arboviroses, tularaemia, plague or scrub typhus, where man acquires the infectious agent after entering a natural focus, commonly by the attack of an haematophagous vector. However, there does not exist a clear distinction between these two groups of zoonoses, and a number of zoonoses exhibit both urban and sylvatic patterns of circulation – yellow fever, American trypanosomiasis, plague.

Sapronoses are diseases transmissible to man from an abiotic substrate in the environment – soil, water, decaying plants, animal excrement, carrion and other substrata. The most important feature is that the sapronotic agent replicates actively in these abiotic substrata – it is not the mere persistence of the microbe in the environment, nor secondary contamination of environmental objects with the agent from animal sources. The source of infection is therefore not an animal or man. Sapronotic agents are capable of reproduction both in abiotic environment (saprophytic phase) and in the organisms of homoiothermous vertebrates including man (parasitic phase). They show a “dual life”: saprophytic and parasitic (pathogenic). In particular, many human mycoses belong to sapronoses, especially visceral ones, like coccidioidomycosis, histoplasmosis, blastomycosis, emmonsiosis, cryptococcosis, and also some bacterial (legionellosis) and protozoan (primary amoebic meningoencephalitis, naegleriosis) diseases, but no viral, rickettsial or chlamydial diseases (because obligate intracellular parasites are unable to reproduce extracelullarly).

The term “sapronosis” and its definition were introduced into epidemiology by Russian microbiologist V. I. Terskikh (1958) in the article entitled “On diseases of humans and animals caused by microbes capable of reproduction in external milieu …”, and for further use it was accepted by Somov and Litvin (1988), Krauss et al. (1997), Hubálek (2003) and others. The definition of sapronoses reads after Krauss et al. (1997): Krankheiten, deren Erreger keine Wirbeltiere als Reservoir erfordern, weil sie in Wasser, Boden, auf Pflanzen usw. vorkommen und von dort aus auch Vertebraten infizieren können.

The difference between zoonoses and sapronoses is sometimes fuzzy to vague, and a disease can be called, depending on circumstances, either zoonosis or sapronosis (e.g., listeriosis, pseudotuberculosis, anthrax).

A characteristic feature of a majority of zoonoses and sapronoses is that man is a dead-end host in the epidemic process (inter-human transmission is absent), although his or her disease can often be serious, even fatal. The pathogenic agent is evolutionarily not adapted to its accidental new host. From an ecological point of view, all pathogenic microorganisms are parasites of their hosts (animals or plants). The evolution of parasitism in today’s pathogens proceeded along the trajectory saprophyte (commensal) → facultative (occasional) parasite → obligate parasite. An obligate parasite as a rule does not kill its host on which it is evolutionarily adapted (the untimely death of the host would lead to a bad fate for it), while unusual, incidental but susceptible hosts (man in our case) where parasitic co-evolution has not occurred can be severely harmed or killed.

Classification of infectious diseases into anthroponoses, zoonoses and sapronoses is a combination of an anthropocentric view (i.e. treating only diseases of humans, while not those of animals) and ecological view (studying the habitats in which the infectious agent lives: Hubálek 2002).

We can distinguish six classes of zoonoses and sapronoses according to systematic arrangement of their aetiological agents:
I

Viroses

II

Bacterial diseases

III

Mycoses

IV

Protozoan diseases

V

Helminthoses (invasions: cestodes, trematodes, nematodes)

VI

Diseases caused by arthropods (infestations)

However, we will concentrate on microbial zoonoses and sapronoses in this monograph, leaving aside diseases caused by multicellular organisms (helminths and arthropods, i.e. invasions and infestations). The agents of the classes IV–VI belong to the field of parasitology, and cause the so-called parasitic zoonoses and sapronoses.

Literature

  1. Hubálek Z (2003) Emerging human infectious diseases: anthroponoses, zoonoses, and sapronoses. Emerg Infect Dis 9: 403–404.PubMedGoogle Scholar
  2. Krauss H, Weber A, Enders B, Schiefer HG, Slenczka W, Zahner H (1997) Zoonosen, 2. Aufl. Deutscher Ärzte, Köln. p. 400.Google Scholar
  3. Somov GP, Litvin VJ (1988) Saprophytic and parasitic life of pathogenic microorganisms (in Russian). Nauka, Novosibirsk. p. 207.Google Scholar
  4. Terskikh VI (1958) Diseases of man and animals caused by microorganisms capable of replication in external milieu (in Russian). Zhurn Mikrobiol Epidemiol Immunobiol 8: 118–122.Google Scholar

Copyright information

© Springer Netherlands 2010

Authors and Affiliations

  1. 1.Institute of Vertebrate Biology, v.v.i.Academy of Sciences of the Czech RepublicBrnoCzech Republic
  2. 2.Faculty of Science, Institute of Experimental BiologyMasaryk UniversityBrnoCzech Republic

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