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Biological Activities of Snake Venom Metalloproteinases on Platelets, Neutrophils, Endothelial Cells, and Extracellular Matrices

  • Chun-Chieh Hsu
  • Tur-Fu HuangEmail author
Chapter

Abstract

Snake venom metalloproteinases (SVMPs) may be classified into P-I~P-IV SVMP. P-I and P-III groups are abundant in viper venoms, and preserve proteolytic activity. These zinc-dependent SVMPs have profound effects on cellular receptors, plasma proteins and extracellular matrices, and thus affecting haemostasis. In this review, we focus on their interaction with platelet glycoprotein (GP) Ib, GP VI, integrin α2β1, neutrophil PSGL-1, endothelial adherens junction, plasma vWF, fibrinogen and other extracellular matrix, e.g. collagen, in causing antiplatelet, antiinflammation, and endothelial apoptosis. In addition, the in vivo antithrombotic and hemorrhagic activities of these SVMPs are also explored. Through these structure-activity relationship studies using SVMPs as tools for elucidating the ligand-receptor interaction, we may devise useful antidotes for thrombosis, inflammation and human victims of snake envenoming.

Keywords

Snake Venom Protease Domain Coagulation Factor VIII Venom Component Metalloproteinase Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Institute of Pharmacology, College of Medicine, National Taiwan UniversityTaipeiTaiwan
  2. 2.Graduate Institute of Pharmacology, College of Medicine, National Taiwan UniversityTaipeiTaiwan

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