Snake Venomics, Antivenomics, and Venom Phenotyping: The Ménage à Trois of Proteomic Tools Aimed at Understanding the Biodiversity of Venoms

Abstract

This review covers the application of proteomic protocols (“venomics”, “antivenomics”, and “venom phenotyping”) to studying the composition and natural history of snake venoms, and the crossreactivity of antivenoms against homologous and heterologous venoms. Toxins from the same protein family present in venoms from snakes belonging to different genera often share antigenic determinants. This circumstance offers the possibility of defining the minimal set of venoms containing the epitopes necessary to generate therapeutic broad-range polyvalent antisera. Recent work shows how the knowledge of evolutionary trends along with venom phenotyping may be used to replace the traditionally used phylogenetic hypothesis for antivenom production strategies by cladistic clustering of venoms based on proteome phenotype and immunological profile similarities.

Keywords

Snake Venom Venom Gland Crude Venom Venom Protein Venom Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The author gratefully thank the many colleagues (particularly from the Instituto Clodomiro Picado, Costa Rica) who, over the years, have provided precious venoms and antivenoms within the framework of collaborative projects and have contributed insight and suggestions. Funding for the projects described in this paper was provided by grant BFU2007-61563 from the Ministerio de Educación y Ciencia, Madrid, CRUSA-CSIC (2007CR0004), and CYTED (206AC0281). Travelling between Spain and Costa Rica was financed by Acciones Integradas, 2006CR0010 between CSIC and the University of Costa Rica (UCR).

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Laboratorio de Proteinómica EstructuralInstituto de Biomedicina de Valencia, CSICValenciaSpain

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