Summary and Outlook

  • Kurt Hellmann
  • Walter Rhomberg
Chapter

Abstract

Razoxane (Rz) and dexrazoxane (DXRz) have several interesting modes of action. They block the cell division at the level of G2/M in the cell cycle, they have shown antiinvasive activity in preclinical experiments, and they are able to normalize pathological tumour blood vessels. In addition, the drugs inhibit topoisomerase II α (the full implications have yet to emerge) and they are powerful chelating agents which not only chelate iron, but also a variety of other ions such as zinc, magnesium, lead, cadmium and copper.

Keywords

Diabetic Retinopathy Soft Tissue Sarcoma Vinca Alkaloid Dimethyl Hydrazine Preclinical Experiment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Kurt Hellmann
    • 1
  • Walter Rhomberg
    • 2
  1. 1.Windleshaw HouseWithyhamUK
  2. 2.BludenzAustria

Personalised recommendations