HDL-Cholesterol Is Protective
Cholesterol (being insoluble in water) all has to be carried in plasma in lipoproteins. Most is in low density lipoprotein (LDL), whose concentration is higher in CHD cases. But one-quarter to one-third of plasma total cholesterol is in high-density lipoprotein (HDL). There were some observations in the 1950s that HDL-cholesterol levels (HLD-c) were lower with CHD. The concept that HDL-c might be PROTECTIVE started with the Millers’ 1975 discovery that is was inversely related to body total cholesterol pools. Supportive epidemiology reports followed. Higher HDL-c levels help to explain the lower (age-standardised) incidence of CHD in women. Dietary influences on HDL-c are quite different from those that affect plasma LDL-cholesterol and total cholesterol (since LDL-predominates in plasma). Years 1953–1979.