Central Nervous System Rosai–Dorfman Disease

  • Osama Raslan
  • Leena M. Ketonen
  • Gregory N. Fuller
  • Dawid Schellingerhout
Chapter
First Online:
Part of the Methods of Cancer Diagnosis, Therapy and Prognosis book series (HAYAT, volume 8)

Abstract

In 1969, Rosai and Dorfman described the triad of massive cervical lymphadenopathy, expanded lymph node sinuses and characteristic histiocytes showing “emperipolesis” as a new, rare, idiopathic, nonneoplastic, lymphoproliferative disorder known as Rosai Dorfman Disease (RDD) or ‘sinus histiocytosis with massive lymphadenopathy (SHML) (Rosai and Dorfman 1969). Since then, over 750 cases have been reported in the literature (Hargett and Bassett 2005). Typically, RDD is characterized by bilateral painless cervical lymphadenopathy with fever, leukocytosis, increased erythrocyte sedimentation rate and hypergammaglobulinaemia (Chopra et al. 2006). However, in approximately 40% of cases, extranodal lesions in the skin, upper respiratory tract, orbit, testicle, soft tissue, kidney, thyroid, small bowel, breast, and bone can be found (Ruggiero et al. 2006).

Keywords

Apparent Diffusion Coefficient Lymphoproliferative Disorder Hemophagocytic Lymphohistiocytosis Rosai Dorfman Disease Benign Meningioma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Netherlands 2011

Authors and Affiliations

  • Osama Raslan
    • 1
  • Leena M. Ketonen
    • 1
  • Gregory N. Fuller
    • 1
  • Dawid Schellingerhout
    • 1
  1. 1.Department of Diagnostic Radiology, National Cancer CenterCairo UniversityCairoEgypt

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