Combination Therapy: Complexing of QDs with Tetrapyrrols and Other Dyes

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Abstract

Analysis of recent works on investigation of photophysical properties of the complexes formed by the colloidal semiconductor quantum dots (QDs) and tetrapyrrol substances in liquid solution as well as the mechanisms of the complex formation was performed with the aim of utilization of the complexes in the cancer photodynamic therapy as a new approach in the combination therapy. It is demonstrated that the use of QDs as the energy donor allows to substantially extend spectral range of the complexes absorption and, therefore, to widen the set of the appropriate light sources for activation of sensitizer molecule in the complex. Besides the efficient energy transfer from QD to the tetrapyrrol molecule, it was shown that the molecule retains the capability of singlet oxygen generating with high quantum yield. Two solutions of the problem of delivery of the exciting radiation to the cancer cells due to strong absorption of the visible light by biological tissues are considered: (1) Two-photon activation of the QD/photosensitizer complex by using light in the 700–1,200 nm spectral range where the biological tissues have a minimal absorption. (2) X-ray activation of the QD/photosensitizer complex. The results of the analysis of existing works demonstrate that the QD/tetrapyrrol complexes have a large potential for application in PDT.

Keywords

Singlet Oxygen Fluorescence Resonance Energy Transfer Singlet Oxygen Generation Luminescence Quantum Yield Fluorescence Resonance Energy Transfer Efficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Vladimir Maslov
    • 1
  • Anna Orlova
    • 2
  • Alexander Baranov
    • 2
  1. 1.Center of Information Optical TechnologiesSaint-Petersburg State University of Information Technologies, Mechanics and Optics Saint-PetersburgSt. PetersburgRussia
  2. 2.St. Petersburg State University of Information Technologies, Mechanics and OpticsSt. PetersburgRussia

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