Molecular Chaperones as Mediators of Stress Protective Effect of Plant Adaptogens

  • Alexander Panossian
  • Georg Wikman
  • Punit Kaur
  • Alexzander Asea
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 5)

Abstract

The ability of plant adaptogens to enhance the “state of non-specific resistance” of an organism to stress by augmenting resistance to physical, biological, chemical and psychological stresses, and increasing concentration, performance and endurance during fatigue have placed it in a unique position among medicinal plants. However, the molecular mechanism by which plant adaptogens exerts its beneficial effects is thus far incompletely understood. This chapter focuses on recent advances in the understanding the molecular mechanism exerted by ADAPT-232 forte, a plant adaptogens consisting of a fixed combination of three extracts of Eleutherococcus senticocus, Schisandra chinensis and Rhodiola rosea. Our studies suggest that ADAPT-232 exerts its beneficial effect, in part, by a mechanism dependent on the upregulation of Hsp70 expression. A concise discussion of the effect of adaptogens on endurance and a comparison of hormetins and adaptogens will also be discussed

Keywords:

Adaptogens Eleutherococcus senticocus heat shock proteins hormesis longevity Rhodiola rosea Schisnadra chinesis 

Abbreviations

DAF-16

forkhead box O transcription factor protein

daf-16

forkhead box O transcription factor gene

HPA

hypothalamic-pituitary-adrenal

HSF-1

heat shock factor-1 protein

hsf-1

heat shock factor-1 gene

Hsp72

seventy kilo Dalton stress-inducible heat shock protein

IGF-I

insulin-like growth factor 1

JNK

c-Jun N-terminal kinase

JKK

c-Jun N-terminal kinase kinase

LD

lethal dose

NADPH

nicotinamide adenine dinucleotide phosphate

NOAEL

no observable adverse effect level

RNAi

RNA interference

TNF-α

tumor necrosis factor-alpha

TTE

time taken to exhaustion

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Alexander Panossian
    • 1
    • 2
  • Georg Wikman
    • 1
  • Punit Kaur
    • 3
  • Alexzander Asea
    • 3
  1. 1.Swedish Herbal Institute Research and DevelopmentÅsklosterSweden
  2. 2.Swedish Herbal Institute Research and DevelopmentÅsklosterSweden
  3. 3.Division of Investigative PathologyThe Texas A&M Health Science Center College of Medicine, Scott & White Memorial Hospital and ClinicTempleUSA

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