Role of Human Papillomavirus in Tonsillar Cancer

  • Eva Munck-WiklandEmail author
  • Lalle Hammarstedt
  • Hanna Dahlstrand
Part of the Methods of Cancer Diagnosis, Therapy and Prognosis book series (HAYAT, volume 7)


Tonsillar cancer is the most common of the oropharyngeal malignancies and belongs to the group of head and neck cancer that originate in the Waldeyer’s ring. Smoking and alcohol are regarded as the main etiological factors for head and neck squamous cell carcinoma (HNSCC), but these tumors also occur in some 15-20% of patients without these risk factors. Accumulating data indicate that high risk human papillomavirus (HPV) is associated with a subgroup of HNSCC mainly oropharyngeal cancer (Gillison and Shah 2001; Mellin et al. 2000), and studies indicate that a history of smoking and high-risk HPV seropositivity, together, increase the risk for HNSCC suggesting that there is either an additive or synergistic relationship between these two risk factors.


Oropharyngeal Cancer Tongue Cancer Tonsillar Cancer Type Specific Polymerase Chain Reaction p16INK4a Staining 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Eva Munck-Wikland
    • 1
    Email author
  • Lalle Hammarstedt
    • 1
  • Hanna Dahlstrand
    • 1
  1. 1.Department of Otorhinolaryngology Head and Neck SurgeryKarolinska University HospitalStockholmSweden

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