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Mechanostransduction in Cardiac and Stem-Cell Derived Cardiac Cells

  • Jeffrey G. Jacot
  • Anna J. Raskin
  • Jeffrey H. Omens
  • Andrew D. McCulloch
  • Leslie Tung
Chapter
Part of the Mechanosensitivity in Cells and Tissues book series (MECT, volume 3)

Abstract

This review focuses on mechanoelectric feedback and mechanotransduction in cardiac cells and stem-cell derived cardiomyocyte progenitor cells. Topics include: methods to apply mechanical stimuli to isolated cells and tissues; methods for patterned growth of cells; effects of stretch and shear stress on cellular function and tissue electrophysiology; regulation of structural and junctional proteins by stretch; the role of the cytoskeleton in mechanotransduction and heart failure; signaling pathways involved in mechanotransduction and load-induced hypertrophic responses; and the role of substrate stiffness in stem cell differentiation and maturation of excitation-contraction coupling.

Keywords

Сardiomyocytes Mechanical stimulation Mechanotransduction Signaling pathways 

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Jeffrey G. Jacot
    • 1
  • Anna J. Raskin
    • 2
  • Jeffrey H. Omens
    • 3
  • Andrew D. McCulloch
    • 3
  • Leslie Tung
    • 4
  1. 1.Department of BioengineeringRice University, Congenital Heart Surgery, Texas Children’s HospitalHoustonUSA
  2. 2.Saint Jude MedicalLos AngelesUSA
  3. 3.Department of BioengineeringUniversity of CaliforniaSan DiegoUSA
  4. 4.Department of Biomedical EngineeringThe Johns Hopkins UniversityBaltimoreUSA

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