Security Issues Related to Synthetic Biology

Between Threat Perceptions and Governance Options
Chapter

Abstract

Given the historical pattern of misuse of advances in the life sciences, the biosecurity implications of synthetic biology deserve close attention. This requires in the first instance a clear understanding of the differences between traditional biosafety concerns and potential biosecurity threats. After discussing the meaning attached to these terms, the paper moves on to analyse the biosecurity awareness of synthetic biologists in Europe in relation to several of the key events in the evolving biosecurity discourse. Following the analysis of interview results that reveal a low to medium level of biosecurity awareness on the part of European synthetic biologists, biosecurity governance mechanisms are evaluated that have been proposed up to now. These put either a heavy emphasis on self-governance by the synthetic biology community, or focus on technical solutions to address biosecurity risks. Expanding on these proposals the chapter outlines a new 5P-strategy for synthetic biology biosecurity governance which revolves around a set of measures being identified that could be brought to bear at the identified five policy intervention points.

References

  1. Australia Group (2006) List of Biological Agents for Export Control, July 2006, Available at: http://www.australiagroup.net/en/biologicalagents.html
  2. Australia Group (2007) Australia Group Homepage, Available at: http://www.australiagroup.net
  3. Balmer A and Martin P (2008) Synthetic Biology, Social and Ethical Challenges, An Independent Review Commissioned by the Biotechnology and Biological Sciences Research Council (BBSRC)http://www.bbsrc.ac.uk/organisation/policies/reviews/scientific_areas/0806_synthetic_biology.pdf
  4. Bhutkar A (2005) Synthetic Biology: Navigating the Challenges Ahead, Journal of Biolaw and Business 8(2):9–29Google Scholar
  5. Bügl H, Danner JP, Molinari RJ, Mulligan JT, Park H-O, Reichert B, Roth DA, Wagner R, Budowle B, Scripp R, Smith JAL, Steele SJ, Church G and Endy D (2007) DNA Synthesis and Biological Security, Nature Biotechnology 25(6):627–629PubMedCrossRefGoogle Scholar
  6. Carlson R (2003) The Pace and Proliferation of Biological Technologies, Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science 1(3):203–214CrossRefGoogle Scholar
  7. Choffnes ER, Lemon SM and Relman DA (2006) A Brave New World in the Life Sciences, The Breadth of Biological Threats is Much Broader than Commonly Thought and Will Continue to Expand, Bulletin of the Atomic Scientists 62(5):26–33CrossRefGoogle Scholar
  8. Church GM (2004) A Synthetic Biohazard Non-Proliferation Proposal, http://arep.med.harvard.edu/SBP/ChurchBiohazard04c.html
  9. Conferees, SB2.0 (2006) Public Draft of the Declaration of the Second International Meeting on Synthetic Biology, http://hdl.handle.net/1721.1/32982
  10. Dando MR (1999) The Impact of the Development of Modern Biology and Medicine on theEvolution of Modern Biological Warfare Programmes in the Twentieth Century, Defense Analysis 15(1):51–65Google Scholar
  11. European Commission (2005) Synthetic Biology: Applying Engineering to Biology, Report of a NEST High-Level Expert Group, European Commission, BrusselsGoogle Scholar
  12. de Vriend H (2006) Constructing Life, Early Social Reflections on the Emerging Field of SB, Den Haag, Rathenau Instituut, http://www.rathenau.nl/downloadfile.asp?ID=1101 Google Scholar
  13. ETC Group (2006) Synthetic Biology – Global Societal Review Urgent, Background document, 17 May, http://www.etcgroup.org/upload/publication/pdf_file/11
  14. ETC Group (2007) Syns of Omission: Civil Society Organizations Respond to Report on Synthetic Biology Governance from the J. Craig Venter Institute and Alfred P. SloanFoundation, press release, 17 October, 2007,http://www.etcgroup.org/en/materials/publications.html?pubId=654
  15. Garfinkel MS, Endy D, Epstein GL and Friedmann RM (2007) Synthetic Genomics: Options for Governance,http://www.jcvi.org/cms/fileadmin/site/research/projects/synthetic-genomics-report/synthetic-genomics-report.pdf
  16. Implementation Support Unit (2008a) Biosafety and Biosecurity, UN document BWC/MSP/2008/MX/INF.1, Geneva,http://daccessdds.un.org/doc/UNDOC/GEN/G08/618/92/PDF/G0861892.pdf?OpenElement
  17. Implementation Support Unit (2008b) Oversight of Science, UN document BWC/MSP/2008/MX/INF.3, Geneva,http://daccessdds.un.org/doc/UNDOC/GEN/G08/620/84/PDF/G0862084.pdf?OpenElement
  18. Industry Association Synthetic Biology (2008) Report on the Workshop “Technical Solutions for Biosecurity in Synhtetic Biology”, http://www.ia-sb.eu
  19. International Risk Governance Council (2008) Concept Note Synthetic Biology, Risks and Opportunities of an Emerging Field, Geneva, http://www.irgc.org/IMG/pdf/IRGC_ConceptNote_SyntheticBiology_Final_30April.pdf
  20. Kelle A (2007) Synthetic Biology and Biosecurity Awareness in Europe, Vienna, IDC, http://www.synbiosafe.eu/uploads///pdf/Synbiosafe-BiosecurityawarenessinEuropeKelle.pdf Google Scholar
  21. Maurer SM and Zoloth L (2007) Synthesising Biosecurity, Bulletin of the Atomic Scientists 63(6):16–18CrossRefGoogle Scholar
  22. Maurer SM, Lucas KV and Terrell S (2006) From Understanding to Action: Community-Based Options for Improving Safety and Security in Synthetic Biology, Berkeley: Goldman School of Public Policy, University of California, Draft 1.1, 15 AprilGoogle Scholar
  23. National Research Council (2004) Biotechnology Research in an Age of Terrorism, Committee on Research Standards and Practices to Prevent the Destructive Application of Biotechnology, Washington, D.C., The National Academies PressGoogle Scholar
  24. National Research Council (2006) Globalization, Biosecurity, and the Future of the Life Sciences, Committee on Advances in Technology and the Prevention of Their Application to Next Generation Biowarfare Threats, Washington, D.C., The National Academies PressGoogle Scholar
  25. NSABB (2006) Addressing Biosecurity Concerns Related to the Synthesis of Select Agents, Washington, D.C.,http://oba.od.nih.gov/biosecurity/pdf/FinalNSABBReportonSyntheticGenomics.pdf
  26. O’Malley MA, Powell A, Davies JF and Calvert J (2008)Knowledge-making Distinctions in Synthetic Biology, BioEssays 30:57–65PubMedCrossRefGoogle Scholar
  27. Petro JB, Plasse TR and McNulty, JA (2003) Biotechnology: Impact on Biological Warfare and Biodefense, Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science 1(3):161–168CrossRefGoogle Scholar
  28. POST (Parliamentary Office of Science and Technology) (2008).Synthetic Biology, Postnote 298, London, http://www.parliament.uk/documents/upload/postpn298.pdf
  29. Schmidt M (2008) Diffusion of synthetic biology: A challenge to biosafety, Systems and Synthetic Biology, DOI: 10.1007/s11693-008-9018-zGoogle Scholar
  30. Schmidt M, Biller-Andorno N, Deplazes A, Ganguli-Mitra A, Kelle A and Torgersen H (2008) Background Document for the SYNBIOSAFE e-conference,http://www.synbiosafe.eu/uploads///pdf/SYNBIOSAFE-backgroundpaper2008.pdf
  31. Selgelid MJ (2007) A Tale of Two Studies: Ethics, Bioterrorism and the Censorship of Science, Hastings Center Report 37,http://www.synbiosafe.eu/uploads///pdf/Tale20Two20Studies20Final20Printed.pdf
  32. Serrano L (2007) Synthetic biology: Promises and challenges, Molecular Systems Biology 3:158PubMedCrossRefGoogle Scholar
  33. Steinbruner JD (2002) Protective Oversight of Biotechnology: A Discussion Paper, http://www.cissm.umd.edu/papers/files/biotechoversight.pdf
  34. Steinbruner JD, Harris ED, Gallagher N and Okutani SM (2007) Controlling Dangerous Pathogens, A Prototype Protective Oversight System, College Park: University of Maryland, http://www.cissm.umd.edu/papers/files/pathogensprojectmonograph.pdf
  35. SYNBIOSAFE (2008) Compilation of all SYNBIOSAFE e-conference contributions, http://www.synbiosafe.eu/uploads/pdf/Synbiosafe_e-conference_all_contributions.pdf
  36. Tucker JB and Zilinskas RA (2006) The Promise and Perils of Synthetic Biology, New Atlantis (Washington, D.C.) 12:25–45PubMedGoogle Scholar
  37. van Est R, de Vriend H and Walhout B (2007)Constructing Life, The World of Synthetic Biology, http://www.rathenau.nl/downloadfile.asp?ID=1331
  38. World Health Organisation (2004) Laboratory Biosafety Manual, 3rd Edition, Geneva, http://www.who.int/csr/resources/publications/biosafety/WHO_CDS_CSR_LYO_2004_11/en/
  39. World Health Organisation (2006) Biorisk Management, Laboratory Biosecurity Guidance, Geneva,http://www.who.int/csr/resources/publications/biosafety/WHO_CDS_EPR_2006_6.pdf

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  1. 1.Department of European Studies and Modern LanguagesUniversity of BathClaverton DownUK
  2. 2.Organisation for International Dialogue and Conflict Management (IDC)Biosafety Working GroupViennaAustria

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