Vademecum permanente nascholing huisartsen pp 1329-1330 | Cite as
Kan norfloxacine congenitale afwijkingen veroorzaken?
Chapter
Samenvatting
Norfloxacine (Noroxin®) is een gefluorideerde chinolonverbinding. Het bactericide-effect berust op beïnvloeding van de DNA-synthese door remming van het bacteriële DNA-gyrase. Het brede werkingsspectrum van de chinolonen omvat bijna alle Gramnegatieve en een aantal Gram-positieve bacteriën.
Literatuur:
- Corrado ML, et al. Review of safetystudies. Am J Med 1987; 82: 22-26.Google Scholar
- Gough AW, et al. Quinolone arthropathy-acute toxicity to immature cartilage. Toxicology 1992; 20: 436-50.Google Scholar
- Stahlmann R, Förtser C, Sickle D van. Quinolones in children. Drug Saf 1993; 9: 397-403.Google Scholar
- Pino A, Maura A, Villa F, Masciangelo L. Evaluation of DNA damage induced by norfloxacin in liver and kidney of adult rats and in fetal tissues after transplacental exposure. Mutat Res 1991; 264: 81-85.Google Scholar
- Ikura T, et al. In: Shepard TH. Catalog of Teratogenic Agents, 4th ed. Baltimore: John Hopkins University Press, 1986: 423-24.Google Scholar
- Cukierski MA, et al. Embryotoxicity studies of norfloxacin in Cynomegalusmonkeys: I Teratology studies and norfloxacin plasmaconcentration in pregnant and nonpregnant monkeys. Teratology 1989; 39: 39-52.Google Scholar
- Berkovitch M, Pastuszak A, Gazarian M, Lewis M, Koren G. Safety of the new quinolones in pregnancy. Obstet Gynecol 1994; 84: 535-38.Google Scholar
- Andreou R, Schick B, Sage S, Cook l, Donnefeld A, Koren G. New postmarketing surveillance data supports a lack of association between quino lone use in pregnancy and fetal and neonatal complications. Reprod Toxicol 1991; 9: 584.Google Scholar
- Schaefer C, et al (ENTIS). Pregnancy outcome after prenatal exposure. Europ J Obstet Gynec 1996; 69: 83-89.Google Scholar
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© Bohn Stafleu van Loghum 2006