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Stimulerende middelen: Amfetamine

  • Henk van Wilgenburg

Amfetamine, en het nauw verwante methamfetamine, zijn synthetische psychoactieve verbindingen die gerekend worden tot de stimulerende middelen met potentieel verslavende werking. Amfetamine en methamfetamine staan sinds 1976 op lijst 1 van de Opiumwet. Op deze lijst staan harddrugs met een onaanvaardbaar risico voor de gezondheid. Produceren, verhandelen en bezitten van harddrugs is strafbaar. Voordat het zover was gekomen had amfetamine al een bewogen geschiedenis achter de rug als geneesmiddel en als middel voor recreatief gebruik.

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Referenties

  1. Cami J, Farre M. Drug addiction. New Engl journ of medici 2003; 349: 975–986.CrossRefGoogle Scholar
  2. Chang L, Ernst T, Speck O, Patel H, DeSilva M, Leonido-Yee M, Miller EN. Perfusion MRI and computerized cognitive test abnormalities in abstinent methamphetamine users. Psychiatry research 2002; 114: 65–79.PubMedCrossRefGoogle Scholar
  3. Cho AK. Ice: a new dosage form of an old drug. Science 1990 249: 631–634.PubMedCrossRefGoogle Scholar
  4. Gouzoulis-Mayfrank E, Daumann J, Sass H. Long-term neurotoxic brain damage in ecstasy (MDMA) users. A review of the literature. Nervenarzt 2002; 73: 405–421.Google Scholar
  5. Harris DS, Boxenbaum H, Everhart ET, Sequeira G, Mendelson JE, Jones RT. The bioavailability of intranasal and smoked methamphetamine. Clinical pharmacology & therapeutics 2003; 74: 475–486.CrossRefGoogle Scholar
  6. Heikkila RE, Orlansky H, Mytilineou C, Cohen G. Amphetamine: evaluation of d- and l-isomers as releasing agents and uptake inhibitors for 3H-dopamine and 3H-norepinephrine in slices of rat neostriatum and cerebral cortex. The journ of pharmaco and experimen therapeu 1975 194: 47–56.Google Scholar
  7. 151202 Jenkins AJ, Cone EJ. Pharmacokinetics: drug absorption, distribution, and elimination: In Steven B, Karch MD, editors. Drug abuse handbook. San Francisco: CRC Press; 1988: 151–202.Google Scholar
  8. Jernigan TL, Gams AC, Archibald SL, Fennema-Notestine C, Mindt MR, Marcotte TL, Heaton RK, Ellis RJ, Grant I. Effects of Methamphetamine Dependence and HIV Infection on Cerebral Morphology. American journal of psychiatry 2005; 162: 1461–1472.PubMedCrossRefGoogle Scholar
  9. Jones S, Bonci A. Synaptic plasticity and drug addiction. Current opinion in pharmacology 2005; 5: 20–25.PubMedCrossRefGoogle Scholar
  10. Kita T, Wagner GC, Nakashima T. Current research on methamphetamine-induced neurotoxicity: animal models of monoamine disruption. Journ of Pharma Sciences 2003; 92: 178–195.CrossRefGoogle Scholar
  11. Kogan FJ, Nichols WK, Gibb JW. Infl uence of methamphetamine on nigral and striatal tyrosine hydroxylase activity and on striatal dopamine levels. Eur Journ of Pharma 1976; 36: 363–371.CrossRefGoogle Scholar
  12. Laar MW van, Cruts AAN, Verdurmen JEE, Ooyen-Houben MMJ van, Meijer RF. Jaarbericht Nat Drug Monitor 2006. Utrecht: Trimbos-instituut; 2006.Google Scholar
  13. Lyvers M. Recreational ecstasy use and the neurotoxic potential of MDMA: current status of the controversy and methodological issues. Drug and Alcohol Review 2006; 25: 269–276.PubMedCrossRefGoogle Scholar
  14. Maure HH, Kraemer T, Springer D, Staack RF. Chemistry, Pharmacology, Toxicology, and Hepatic Metabolism of Designer Drugs of the Amphetamine (Ecstasy), Piperazine, and Pyrrolidinophenone Types: A Synopsis. Therapeutic drug monitoring 2004; 26: 127–131.CrossRefGoogle Scholar
  15. McCann UD, George AR. Amphetamine neurotoxicity: accomplishments and remaining challenges. Neuroscience and Biobehavioral Reviews 2004; 27: 821–826.PubMedCrossRefGoogle Scholar
  16. Reneman L, Booij J, Lavalaye J, Bruin K de, Reitsma JB, Gunning WB, Heeten GJ den, Brink W Van Den. Use of amphetamine by recreational users of ecstasy (MDMA) is associated with reduced striatal dopamine transporter densities: a [123I] -CIT SPECT study - preliminary report. Psychopharmacology 2002 159: 335–340.PubMedCrossRefGoogle Scholar
  17. Robinson TE, Becker JB, Moore CJ, Castaneda E, Mittleman G. Enduring enhancement in frontal cortex dopamine utilization in an animal model of amphetamine psychosis. Brain Research 1985 343: 374–377.PubMedCrossRefGoogle Scholar
  18. Robinson TE, Kolb B. Structural plasticity associated with exposure to drugs of abuse. Neuropharmacology 2004; 47: 33–46.PubMedCrossRefGoogle Scholar
  19. Seiden LS, Fischman MW, Schuster CR. Long-term methamphetamine induced changes in brain catecholamines in tolerant rhesus monkeys. Drug and alcohol dependence 1976; 1: 215–219.CrossRefGoogle Scholar
  20. Seiden LS, Sabol KE. Methamphetamine and methylenedioxymethamphetamine neurotoxicity: possible mechanisms of cell destruction. NIDA Research Monographs 1996 163: 251–276.Google Scholar
  21. Sulzer D, Chen TK, Lau YY, Kristensen H, Rayport S, Ewing A. Amphetamine redistributes dopamine from synaptic vesicles to the cytosol and promotes reverse transport. The journ of neuroscience 1995; 15: 4102–4108.Google Scholar
  22. Torre R de la, Farre M, Navarro M, Pacifici R, Zuccaro P, Pichini S. Clinical pharmacokinetics of amfetamine and related substances: monitoring in conventional and nonconventional matrices. Clinical pharmacokinetics 2004; 43: 157–185.PubMedCrossRefGoogle Scholar
  23. Volkow ND, Chang L, Wang GJ, Fowler JS, Franceschi D, Sedler M, Gatley SJ, Miller E, Hitzemann R, Ding YS, Long J. Loss of dopamine transporters in methamphetamine abusers recovers with protracted abstinence. The journal of neuroscience 2001; 21: 9414–9418.PubMedGoogle Scholar
  24. Volkow ND, Chang L, Wang GJ, Fowler JS, Leonido-Yee M, Franceschi D, Sedler MJ, Gatley SJ, Hitzemann R, Ding YS, Logan J, Wong C, Miller EN. Association of dopamine transporter reduction with psychomotor impairment in methamphetamine abusers. Am journ of psychiatry 2001 158: 377–382.CrossRefGoogle Scholar
  25. Volkow ND, Chang L, Wang GJ, Fowler JS, FranceschiD, Sedler MJ, Gatley SJ, Hitzemann R, Ding YS, Wong C, Logan J. Higher cortical and lower subcortical metabolism in detoxified methamphetamine abusers. Am journ of psychiatry 2001 158: 383–389.CrossRefGoogle Scholar
  26. Wolf ME, Sun X, Mangiavacchi S, Chao SZ. Psychomotor stimulants and neuronal plasticity. Neuropharmacology 2004; 47: 61–79.PubMedCrossRefGoogle Scholar

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© Bohn Stafleu van Loghum 2008

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  • Henk van Wilgenburg

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