With recent advances in the techniques and devices used in laparoscopic surgery, the number of surgical teams attempting laparoscopic liver resection has been gradually increasing. The critical determinant for safe laparoscopic hepatectomy is thorough familiarity with laparoscopic instruments and equipment for maintenance of hemostasis. Thermal precoagulation of the liver parenchymal transection plane performed by using microwave energy helps reduce blood loss during parenchymal transection, especially in patients with liver cirrhosis. Currently, 5- to 10-mm-diameter 45° flexible-angle needle probes (Endo-Angle Probe®) are available in minimally invasive surgery including pure endoscopic, and hand- or endoscopy-assisted liver resections. Microwave also allows simultaneous tumor ablation with liver resection, even during laparoscopic procedures for multiple liver tumors. Although laparoscopic liver resection requires careful selection of patients and instrumentation, use of microwave tissue coagulation could contribute to safe laparoscopic liver surgery.