Iatrogenic Lung Damage by Artificial Ventilation: What Is the Role of the Pulmonary Surfactant System?

  • S. Böhm
  • G. F. Vazquez de Anda
  • B. Lachmann
Conference paper

Abstract

Since its introduction for clinical routine use more than 40 years ago, artificial ventilation has proven to be a life-saving method and remains the cornerstone of modern intensive care medicine. Artificial ventilation has also remained a topic of discussion and controversy [1] because it can cause atelectasis, pulmonary edema, pneumonitis, and fibrosis [2]. To date, no adequate explanation of the pathophysiological basis of all these changes has been documented conclusively [3, 4]. However, there is increasing evidence that some of them are induced by alterations of the pulmonary surfactant system [5–10]. We speculate that impairment of the surfactant function is one of the primary causes of ventilation-induced lung injury [11].

Keywords

Adult Respiratory Distress Syndrome Surfactant System Artificial Ventilation Pulmonary Surfactant Large Tidal Volume 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Italia, Milano 1998

Authors and Affiliations

  • S. Böhm
  • G. F. Vazquez de Anda
  • B. Lachmann

There are no affiliations available

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