Cerebrospinal fluid virological analysis in multiple sclerosis
- 136 Downloads
The detection of virus-specific antibodies, of antigens, and the more recent detection of viral nucleic acids in cerebrospinal fluid (CSF) are powerful tools for the diagnosis of the most common viral diseases affecting the CNS, such as acute and subacute encephalomyelitis and other neurological diseases caused by the replication of viruses in the CNS. However, these virological techniques, including those most recently developed, are not so efficient in cases involving the verification of whether a viral agent may be responsible for such a complex disease as multiple sclerosis (MS).
KeywordsPOLYM Erase Chain Reaction mUltiple Sclerosis mUltiple Sclerosis Patient POLYM Erase Chain Reaction Analysis Hemagglutination Inhibition
- 1.Kurtzke JF (1993) Epidemiologic evidence for Multiple Sclerosis as an infection. Clin Mi-crob Rev 6: 382–427Google Scholar
- 3.Adams JM, Imagawa DT (1962) Measles antibodies in multiple sclerosis. Proc Soc Exp Biol Med 3: 562–566Google Scholar
- 7.Reiber H, Lange P (1981) Quantification of virus specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain. Clin Chem 37:1153–1160Google Scholar