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Dermatite atopica: ipotesi igienica

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Estratto

Il termine “ipotesi igienica” fu inizialmente proposto da Strachan per spiegare la relazione inversa tra prevalenza di rinite allergica e numero di fratelli [1]. In particolare, questo effetto risultava essere più significativo quando si consideravano i fratelli più vecchi. L’epidemiologo inglese per primo ipotizzò che le modificazioni dello stile di vita tipiche del mondo occidentale, quali la riduzione del numero dei figli e le migliori condizioni igieniche ambientali, avessero portato ad una riduzione delle malattie infettive con un conseguente spostamento dell’attenzione del sistema immunitario verso gli allergeni e lo sviluppo di malattie allergiche. Una migliore igiene si tradurrebbe in una minore incidenza d’infezioni virali e batteriche nei primi anni di vita e conseguentemente si avrebbe una minor produzione di interferon-gamma (IFN-γ) con marginali opportunità per i T linfociti di maturare verso il fenotipo Th1 (Fig. 1).

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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  1. 1.Clinica PediatricaUniversità degli StudiVerona

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