Primary and Secondary Chemoprevention of Colorectal Cancer
Chemoprevention of colorectal cancer is defined as the use of pharmacological, chemical, or specific dietary agents that are capable of interrupting the carcinogenic process; progression or frank malignancy. Primary chemoprevention occurs when these agents are made available to the population at large. Secondary chemoprevention is used for individuals at high risk. Review of multiple studies in both animal models treated with chemical carcinogens and in small groups of patients at high risk with familial polyposis, sporadic polyps, and ulcerative colitis suggest that secondary chemoprevention is feasible. The most likely candidate agents appear to be supplemental calcium, prostaglandin inhibitors and possibly vitamins C and E when coupled with wheat bran. As yet none of these agents have been sufficiently tested to warrant their use in primary chemoprevention. A prudent diet of low animal fat, high fiber and controlled total calories does not require any additional supplements for the average or low risk population.
Keywordscolorectal cancer chemoprevention
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- Higgenson, J. (1966) Etiological factors in gastrointestinal cancer in man. JNCI 37: 527–545Google Scholar
- Mogadam, M. (1988) Cancer and nutritional misconceptions: a perspective. Am. J. Gastro. 88: 1346–1351Google Scholar
- Silverberg, E. (1988) Cancer facts and figures. American Cancer Society, New York, N.Y.Google Scholar
- Skrypec, D. J., and Bursey, R. G. (1988) Effect of dietary calcium on azoxymethane-induced intestinal carcinogenesis in male F344 rats fed high fat diets FASEB Journal 2: AB57Google Scholar
- Stemmerman, G. N., Heilbrun, L. K., and Nomura, A. M. Y. (1988) Association of diet and other factors with adenomatous polyps in the large bowel: a prospective autopsy study. Am. J. Clin. Nutr. 47: 312–317Google Scholar
- Vogel, V. G. and McPherson (1989) Dietary epidemiology of colon cancer. Hemat./Oncology Clinics of N.America 3:35–63Google Scholar
- Wattenberg, L. (1981) Inhibitors of chemical carcinogens. In: J. D. Burchenal (ed) Cancer Achievements. Challenges, and Prospects for the 1980s Grune and Stratton, New York pp 517–539Google Scholar