Expression of Tenascin in Gastric Cancers and Their Clinicopathological Features
Conference paper
Abstract
We investigated the relationship between tenascin (TN) expression and clinicopathological features in 185 patients with gastric cancers. Histological sections of resected tissues were immunostained using the indirect immunoperoxidase method with mouse monoclonal antibody to TN, and cases with more than 50 % of the tumor stroma demonstrating binding were classified as positive. TN was positive in 37 cases (20%). In this positive group 81.1% were found to be of differentiated type and the mean age was 64.9 years old, these values being significantly higher as compared with the negative group. These results suggest that TN expression may be related to intestinal metaplasia.
Key Words
tenascin extracellular matrix gastric cancerPreview
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© Springer-Verlag Tokyo 1993