Food Factors for Cancer Prevention pp 21-25 | Cite as
Antimutagenesis and Cancer Prevention
Summary
We live in a virtual sea of mutagens and carcinogens. Ultraviolet radiation, components of our foods and beverages, and other substances in the environment are continually assaulting our genomes. Fortunately, nature has provided counteracting systems and substances. Much of the initial damage to our DNA is repaired, and much potential damage is prevented by antimutagens/anticarcinogens. We provide here a brief overview of the important early history of antimutagenesis, describe some of the assay systems used for studying antimutagens, cite briefly some typical results obtained with well known antimutagens, and introduce some discussion of their mechanisms. We conclude with some discussion of the importance of these compounds and suggestions for future research directions we believe could prove beneficial for human health.
Key Words
Antimutagenesis Anticarcinogenesis Prevention Genetoxins MutagensPreview
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References
- 1.Novick A, Szilard L (1951) Experiments on spontaneous and chemically induced mutations of bacteria growing in the che-mostat. Cold Spring Harbor Symp Quant Biol 16:337–342PubMedCrossRefGoogle Scholar
- 2.Sevag MG, Drabble WT (1962) Prevention of the emergence of drug resistant bacteria by polyamines. Biochem Biophys Res Commun 8:446–452PubMedCrossRefGoogle Scholar
- 3.DeCourcy SJ Jr, Barr MM, Blakemore WS, Mudd S (1971) Prevention of antibiotic resistance in vitro in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa by Coumadin. J Infect Dis 123:11–15CrossRefGoogle Scholar
- 4.Heller CS, Sevag MG (1966) Prevention of the emergence of drug resistance in bacteria by acridines phenothiazines and dibenzocycloheptenes. Appl Microbiol 14:879–884PubMedGoogle Scholar
- 5.Clarke CH, Shankel DM (1975) Antimutagenesis in microbial systems. Bacteriol Rev 39:33–53PubMedGoogle Scholar
- 6.Kada T, Tutkikawa K, Sadaie Y (1972) In vitro and host mediated “rec assay” procedures for screening chemical mutagens; and phloxine a mutagenic red dye detected. Mutat Res 16:165–170PubMedCrossRefGoogle Scholar
- 7.Maron DM, Ames BN (1983) Revised methods for the Salmonella mutagenicity test. Mutat Res 113:173–215PubMedCrossRefGoogle Scholar
- 8.Negishi T, Shiotani T, Fujikawa K, Hayatsu H (1991) The genotoxicities of N-nitrosamines in Drosophila melanogaster in vivo: the correlation of mutagenicity in the wing spot test with the DNA damages detected by the DNA-repair test. Mutat Res 252:119–129PubMedCrossRefGoogle Scholar
- 9.Negishi T, Arimoto S, Nishizaki C, Hayatsu H (1989) Inhibitory effect of chlorophyll on the genotoxicity of 3-amino-l-methyl-5H-pyrido-(4,3-b) indole (Trp-P-2). Carcinogenesis 10:145–149PubMedCrossRefGoogle Scholar
- 10.Hayatsu H, Inada N, Kakutani J, Arimoto S, Negishi T, Mori K, Okuda T, Sakata I (1992) Suppression of genotoxicity of carcinogenesis by (-)epigallocatechin gallate. Prev Med 21:370–376PubMedCrossRefGoogle Scholar
- 11.Mitscher LA, Telikepalli H, McGhee EM, Shankel DM (1996) Natural antimutagenic agents. Mutat Res 350:143–152PubMedCrossRefGoogle Scholar
- 12.Ong TM, Whong WZ, Stewart J, Brockman HE (1986) Chlorophyllin: a potent antimutagen against environmental and dietary complex mixtures. Mutat Res 173:111–115PubMedCrossRefGoogle Scholar
- 13.Warner JR, Nath J, Ong T-M (1991) Antimutagenicity studies of chlorophyllin using the Salmonella arabinose-resistant assay system. Mutat Res 262:25–30PubMedCrossRefGoogle Scholar
- 14.Obaseiki-Ebor EE, Odukoya K, Telikepalli H, Mitscher LA, Shankel DM (1993) Antimutagenic activity of extracts of leaves of four common edible plants in Nigeria (West Africa). Mutat Res 302:109–117PubMedCrossRefGoogle Scholar
- 15.Kada T, Kanematsu N (1978) Reduction of N-methyl-N-nitro-N-nitrosoguanidine induced mutations by cobaltous chloride in Escherichia coli. Proc Jpn Acad 54:234–237Google Scholar
- 16.Hartman PE, Shankel DM (1990) Antimutagens and anti-carcinogens: a survey of putative interceptor molecules. Environ Mol Mutagen 15:145–182PubMedCrossRefGoogle Scholar
- 17.DeFlora S, Ramel C (1988) Mechanisms of inhibitors of mutagenesis and carcinogenesis: classification and overview. Mutat Res 202:285–306CrossRefGoogle Scholar
- 18.Pillai S (1995) Prevention and evaluation of antibiotic resistance. PhD dissertation, University of Kansas, Lawrence, KS, USAGoogle Scholar