Oxygen Free Radicals Inhibit Ca2+-pump Activity by Oxidizing Sulfhydryl Groups in Rat Heart Sarcolemmal Membrane

  • Masanori Kaneko
  • Akira Kobayashi
  • Noboru Yamazaki
Conference paper

Abstract

Although oxygen free radicals have been implicated as mediators of cellular injury in some pathophysiological conditions like myocardial ischemia-reperfusion [1], the mechanisms of myocardial cell damage caused by oxygen free radicals are still unclear. In this regard, it should be pointed out that oxygen free radicals are known to attack molecules of major biological significance and these include phospholipids, protein, and nucleic acids [2]. Since sulfhydryl groups (SH groups) are known to regulate the membrane-bound enzyme activities in the cell [3, 4, 5, 6, 7], it is possible that the oxidation of SH groups in the membrane may lead to the depression of enzyme activities because of oxygen free radicals [8].

Keywords

ATPase Activity Xanthine Oxidase Oxygen Free Radical Sulfhydryl Group Pump Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Japan 1992

Authors and Affiliations

  • Masanori Kaneko
    • 1
  • Akira Kobayashi
    • 1
  • Noboru Yamazaki
    • 1
  1. 1.Third Department of Internal MedicineHamamatsu University School of MedicineHamamatsuJapan

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