Anticoagulant Properties of Sulfonated Glucoside-Bearing Polymer

Abstract

Previously, we found that the sulfonated poly(glucosyloxyethyl methacrylate) (poly(GEMA)-sulfate), which bears sulfonated D-(+)-glucose, had anticoagulant activity. In this study, we tried to clarify the mechanism of anticoagulant activity of poly(GEMA)-sulfate. So we carried out activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) tests to recognize the mechanism of anticoagulant activity for poly(GEMA)-sulfate. The results of these in vitro clotting tests showed that poly(GEMA)-sulfate had anticoagulant activity of which mechanism was different from that of heparin. It seems that inhibiting fibrin network formation of anticoagulant may be occurred by the entrapment of fibrinogen by poly(GEMA)-sulfate or inhibiting thrombin activity by the activation of heparin cofactor II.