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HLA class I alleles in Australian aborigines and their peptide binding profiles

  • Xiaojiang Gao
  • Sue Lester
  • Anthony Veale
  • Barry Boettcher
  • Bart Currie
  • James McCluskey
  • Gareth Chelvanayagam

Summary

The HLA system is under balancing selection. HLA alleles are maintained in populations by their divergent functions. The peptide binding profiles of HLA alleles may hold the key to a better understanding of HLA diversification and polymorphism maintenance. Long isolated Australian aboriginal populations provide a good model for these studies. The four HLA-A, seven B and five or six C alleles commonly detected in them represent the minimum class I repertoire carried by the founder group as well as the minimum class I polymorphism that needs to be maintained in these populations. All these alleles have a unique combination of the P2 and P9 anchor preferences indicating unique peptide binding profiles that have ‘earned’ their place in the minimum allele set. This study of Australian aborigines provides further insights into the mechanism of HLA evolution in general.

Key words

Major histocompatibility complex Class I human leucocyte antigen gene Human evolution Peptide presentation Australian aborigines 

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Copyright information

© Springer Japan 2000

Authors and Affiliations

  • Xiaojiang Gao
    • 1
    • 2
  • Sue Lester
    • 3
  • Anthony Veale
    • 4
  • Barry Boettcher
    • 5
  • Bart Currie
    • 6
  • James McCluskey
    • 3
  • Gareth Chelvanayagam
    • 2
  1. 1.IRSP, SAIC Frederick, NCI-FCRDFrederickUSA
  2. 2.Human Genetics Group, John Curtin School of Medical ResearchThe Australian National UniversityCanberraAustralia
  3. 3.Red Cross Blood Transfusion ServiceAdelaideAustralia
  4. 4.National Centre for Epidemiology and Population HealthThe Australian National UniversityCanberraAustralia
  5. 5.Department of Biological SciencesThe University of NewcastleNewcastleAustralia
  6. 6.Menzies School of Health ResearchDarwinAustralia

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