More than a decade has passed since small-bowel capsule endoscopy (CE) was developed. One of the indication for small-bowel CE is suspected/diagnosed Crohn’s disease (CD). Patients who are suspected CD with negative ileocolonoscopy are good candidate for small-bowel CE. In patients with suspected CD, the risk of small-bowel capsule retention is comparable to that when the small-bowel CE is applied for obscure gastrointestinal bleeding. On the other hand, in patients with an established diagnosis of CD, the risk of small-bowel capsule retention is increased, particularly in those with known intestinal stenosis. In the presence of obstructive symptoms or known stenosis, small-bowel cross-sectional imaging or patency capsule, which is a self-dissolving dummy capsule, should generally precede small-bowel CE. Colon CE (CCE) was first reported in 2006. CCE may be appropriate for inflammatory bowel disease; however, the efficacy of CCE on IBD has not been still unconfirmed. A possible application for CCE for IBD is ulcerative colitis.
Video capsule endoscopy Ulcerative colitis Crohn’s disease Patency capsule
This is a preview of subscription content, log in to check access.
Naoki Hosoe received a research grant from Covidien Co. Ltd.
Pennazio M, Spada C, Eliakim R, Keuchel M, et al. Small-bowel capsule endoscopy and device-assisted enteroscopy for diagnosis and treatment of small-bowel disorders: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline. Endoscopy. 2015;47(4):352–86.CrossRefPubMedGoogle Scholar
Mehdizadeh S, Chen GC, Barkodar L, et al. Capsule endoscopy in patients with Crohn's disease: diagnostic yield and safety. Gastrointest Endosc. 2010;71(1):121–7.CrossRefPubMedGoogle Scholar
Papadakis KA, Lo SK, Fireman Z, et al. Wireless capsule endoscopy in the evaluation of patients with suspected or known Crohn’s disease. Endoscopy. 2005;37(10):1018–22.CrossRefPubMedGoogle Scholar
Van Assche G, Dignass A, Panes J, et al. The second European evidence-based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis. J Crohns Colitis. 2010;4(1):7–27.CrossRefPubMedGoogle Scholar
Jensen MD, Nathan T, Rafaelsen SR, et al. Ileoscopy reduces the need for small-bowel imaging in suspected Crohn's disease. Dan Med J. 2012;59(9):A4491.PubMedGoogle Scholar
Bourreille A, Ignjatovic A, Aabakken L, et al. Role of small-bowel endoscopy in the management of patients with inflammatory bowel disease: an international OMED–ECCO consensus. Endoscopy. 2009;41(7):618–37.CrossRefPubMedGoogle Scholar
Yadav A, Heigh RI, Hara AK, et al. Performance of the patency capsule compared with nonenteroclysis radiologic examinations in patients with known or suspected intestinal strictures. Gastrointest Endosc. 2011;74(4):834–9.CrossRefPubMedGoogle Scholar
Cheifetz AS, Kornbluth AA, Legnani P, et al. The risk of retention of the capsule endoscope in patients with known or suspected Crohn's disease. Am J Gastroenterol. 2006;101(10):2218–22.CrossRefPubMedGoogle Scholar
Eliakim R, Fireman Z, Gralnek IM, et al. Evaluation of the PillCam Colon capsule in the detection of colonic pathology: results of the first multicenter, prospective, comparative study. Endoscopy. 2006;38(10):963–70.CrossRefPubMedGoogle Scholar
Van Gossum A, Munoz-Navas M, Fernandez-Urien I, et al. Capsule endoscopy versus colonoscopy for the detection of polyps and cancer. N Engl J Med. 2009;361(3):264–70.CrossRefPubMedGoogle Scholar
Eliakim R, Yassin K, Niv Y, et al. Prospective multicenter performance evaluation of the second-generation colon capsule compared with colonoscopy. Endoscopy. 2009;41(12):1026–31.CrossRefPubMedGoogle Scholar
Spada C, Hassan C, Munoz-Navas M, et al. Second-generation colon capsule endoscopy compared with colonoscopy. Gastrointest Endosc. 2011;74(3):581–9.CrossRefPubMedGoogle Scholar
Spada C, Hassan C, Galmiche JP, et al. Colon capsule endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) guideline. Endoscopy. 2012;44(5):527–36.CrossRefPubMedGoogle Scholar
Negreanu L, Babiuc R, Bengus A, et al. PillCam Colon 2 capsule in patients unable or unwilling to undergo colonoscopy. World J Gastrointest Endosc. 2013;5(11):559–67.CrossRefPubMedPubMedCentralGoogle Scholar
Sung J, Ho KY, Chiu HM, et al. The use of Pillcam Colon in assessing mucosal inflammation in ulcerative colitis: a multicenter study. Endoscopy. 2012;44(8):754–8.CrossRefPubMedGoogle Scholar
Hosoe N, Matsuoka K, Naganuma M, et al. Applicability of second-generation colon capsule endoscope to ulcerative colitis: a clinical feasibility study. J Gastroenterol Hepatol. 2013;28(7):1174–9.CrossRefPubMedGoogle Scholar
Usui S, Hosoe N, Matsuoka K, et al. Modified bowel preparation regimen for use in second-generation colon capsule endoscopy in patients with ulcerative colitis. Dig Endosc. 2014;26(5):665–72.CrossRefPubMedGoogle Scholar
Morita E, Ohtsuka N, Shindo Y, et al. In vivo trial of a driving system for a self-propelling capsule endoscope using a magnetic field (with video). Gastrointest Endosc. 2010;72(4):836–40.CrossRefPubMedGoogle Scholar
Rey JF, Ogata H, Hosoe N, et al. Feasibility of stomach exploration with a guided capsule endoscope. Endoscopy. 2010;42(7):541–5.CrossRefPubMedGoogle Scholar