Dementia with Lewy Bodies

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Clinical Diagnostic Criteria for Dementia with Lewy Bodies

  • Ian G. McKeithAffiliated withNewcastle University Institute for Ageing Email author 

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Clinical diagnostic concepts and methods for the dementias associated with Lewy body disease have evolved over the last three decades to incorporate previously used terminologies including diffuse LB disease (DLBD) [Kosaka et al., Clin Neuropathol 3(5):185–192, 1984; Dickson et al., Acta Neuropathol 75:8–15, 1987; Lennox et al., Lancet 8633(1):323–324, 1989], LB dementia (LBD) [Gibb et al., Brain 110:1131–1153, 1987], dementia associated with cortical Lewy bodies (DCLB) [Byrne et al., Dementia 2:283–284, 1991], the LB variant of Alzheimer’s disease (LBVAD) [Hansen et al., Neurology 40:1–8, 1990; Förstl et al., Br J Psychiatry 162:385–392, 1993] and senile dementia of LB type (SDLT) [Perry et al. J Neurol Sci 95:119–139, 1990]. Dementia with Lewy bodies (DLB) was eventually agreed as a term to include all of these within one set of operationalised consensus criteria [McKeith et al., Neurology 47(5):1113–1124, 1996; McKeith et al. Neurology 65(12):1863–1872, 2005]. These in turn formed the basis for the inclusion of neurocognitive disorder with Lewy bodies (NCDLB) in the latest revision of the DSM5 [APA. Diagnostic and statistical manual of mental disorders: DSM-5. American Psychiatric Association, Washington, DC, 2013]. This formal recognition of DLB as a diagnostic category equivalent to others such as Alzheimer’s disease, vascular disease and frontotemporal disorder will greatly assist recognition and diagnosis of the disorder with benefit for patients and families. It will also enable clinical and research practice and impact upon reimbursement and regulatory authorities. Criteria for early and prodromal diagnosis remain in development.


Clinical Diagnosis Lewy Dementia