Chapter

Dementia with Lewy Bodies

pp 23-39

Date:

Cholinergic Pathology in Dementia with Lewy Bodies

  • John-Paul TaylorAffiliated withInstitute of Neuroscience, Newcastle University Email author 
  • , Daniel CollertonAffiliated withInstitute of Neuroscience, Newcastle University
  • , Fiona LeBeauAffiliated withInstitute of Neuroscience, Newcastle University
  • , Elaine PerryAffiliated withInstitute of Neuroscience, Newcastle University

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Abstract

Cholinergic dysfunction is a major feature of dementia with Lewy bodies (DLB) and makes a significant contribution to the cognitive impairment and other challenging symptoms seen in this condition. Despite this, or indeed, because of this, manipulation of the cholinergic system can offer significant therapeutic opportunities for treating DLB, and this is reflected in the fact that cholinesterase inhibitors remain one of our best treatments in this condition. In this chapter, we will explore the pathology of cholinergic dysfunction in DLB, review findings from both post-mortem and imaging studies and place this within a clinical framework.

Keywords

Cholinergic Dementia with Lewy bodies Acetylcholine