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Innovations in Measuring Cellular Mechanics

  • Navid Bonakdar
  • Achim Schilling
  • Richard Gerum
  • José Luis Alonso
  • Wolfgang H. Goldmann
Chapter

Abstract

This article describes several novel mechanical methods for elucidating cellular responses to different types of mechanical loading (adhesive, pulling, pushing, shearing, and stretching forces). Understanding how cells deform and transmit stresses into the cell is important for gene expression, cytoskeletal remodeling, and focal adhesion reorganization and crucial for a variety of higher fundamental cell functions including cell division, motility, and differentiation. Introducing these unique methods of measuring and understanding cellular mechanics, therefore, provides a valuable platform for cell biology research.

Keywords

Magnetic tweezer Magnetic twisting cytometry Traction force microscopy Cell poking Plate rheometer Nano-scale tracking 

Notes

Acknowledgments

We thank Dr. Ben Fabry for helpful discussions and Dr. Vicky Jackiw for proofreading the manuscript. This work was supported in part by grants from Deutscher Akademischer Austauschdienst (DAAD) and Deutsche Forschungsgemeinschaft (DFG).

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Copyright information

© Springer Japan 2016

Authors and Affiliations

  • Navid Bonakdar
    • 1
  • Achim Schilling
    • 1
  • Richard Gerum
    • 1
  • José Luis Alonso
    • 2
  • Wolfgang H. Goldmann
    • 1
  1. 1.Department of Physics, Biophysics GroupUniversity of Erlangen-Nuremberg/Friedrich-Alexander-University (FAU)ErlangenGermany
  2. 2.Department of MedicineMass. General Hospital/Harvard Medical SchoolCharlestownUSA

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