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Sudden Infant Death Syndrome from Epidemiology to Pathophysiology: Exploring the Connections

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Sudden Infant Death Syndrome

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Abstract

The sudden and unexplained death of sleeping infants aged less than 1 year, the sudden infant death syndrome (SIDS), is still the principal cause of postneonatal mortality in many industrialized countries. Since initiation of education and information campaigns to inform the public on preventable risk factors, SIDS incidence has dropped significantly in most countries. Questions have, however, been raised on the physiological mechanisms underlying the environmental factors increasing the risk for SIDS. From the scientific literature, it appears that various mechanisms responsible for the control of respiratory, cardiac, thermoregulation, neurovegetative, and waking systems could be impaired before or after birth of future victims of SIDS. To understand how various factors contribute to SIDS deaths, we studied the characteristics of sleeping infants in two different populations, in future SIDS victims and in healthy infants exposed to conditions known to favor SIDS. This paper will review research carried out by our laboratory over the past 20 years.

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Authors and Affiliations

  1. Pediatric Sleep Unit, Hôpital Femme Mère Enfant and CRNL INSERM-U1028, CNRS UMR5292 University Lyon 1, 59, boulevard Pinel, 69500, Lyon, France

    P. Franco & A. Raoux

  2. SIDS Reference Center of Lyon, Lyon, France

    B. Kugener

  3. Pediatric Sleep Unit, Children’s University Hospital, Free University of Brussels, Brussels, Belgium

    S. Scaillet & J. Groswasser

  4. Neonatal Research Division, Saitama Medical University, Tokyo, Japan

    I. Kato

  5. Cystic Fibrosis Unit, Department of Paediatric Medicine, Bambino Gesù Children’s Hospital, Rome, Italy

    E. Montemitro

  6. St Petersburg State Pediatric Medical Academy, St Petersburg, Russia

    I. Kelmanson

  7. Institute of Advanced Biomedical Engineering Sciences, Tokyo Women’s Medical University School of Medicine, Tokyo, Japan

    T. Sawaguchi

  8. Paediatric Department, Centre Hospitalo-Universitaire de Besançon, Université de Franche-Comté, Besançon, France

    G. Thiriez

  9. Integrative Physiology of the Arousal Systems, CRNL INSERM-U1028, CNRS UMR5292 University Lyon 1, Medical Faculty, Lyon 1, 8, avenue Rockefeller, 69373, Lyon Cedex 08, France

    J. S. Lin

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  1. P. Franco
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  2. B. Kugener
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  3. S. Scaillet
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  6. E. Montemitro
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  7. I. Kelmanson
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  9. T. Sawaguchi
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  11. J. S. Lin
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  1. Inst of Advanced Biomedical Engineering Tokyo Women's Medical University, Tokyo, Tokyo, Japan

    Toshiko Sawaguchi

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Franco, P. et al. (2014). Sudden Infant Death Syndrome from Epidemiology to Pathophysiology: Exploring the Connections. In: Sawaguchi, T. (eds) Sudden Infant Death Syndrome. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54315-2_3

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