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Effect of a New Calcium Antagonist (SM-6586) on Experimental Cerebral Ischemia

  • Conference paper
Brain Edema IX

Part of the book series: Acta Neurochirurgica ((NEUROCHIRURGICA,volume 60))

  • 167 Accesses

Summary

SM-6586 (SM) is a new derivative of dihydropyridine with potent calcium blocking activity and inhibitory activity of the Na+/ H+ and Na+/Ca++ exchange transport. The effect of SM on survival rate, brain edema and metabolites was evaluated using two different models in spontaneously hypertensive rat (SHR). Global ischemia was induced by bilateral common carotid artery ligation (BLCL) and focal ischemia was induced by middle cerebral artery occlusion. The survival rate after BLCL was higher in the SM-treated group. The brain water content was lower, the ATP level was higher and lactate level was lower in the SM-treated group compared to the control group. In focal ischemia models, the SM-treated group showed a reduction of T1 relaxation time. The brain water content was significantly decreased in the SM-treated group. These results indicate that SM was effective in ameliorating the ischemic insult in global and focal cerebral ischemia models.

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Author information

Authors and Affiliations

  1. Second Department of Internal Medicine, Nippon Medical School, 355 Iidabashi, Chiyoda-ku, Tokyo 102, Japan

    F. Kashiwagi M. D., Y. Katayama, H. Igarashi, S. Iida, H. Muramatsu & A. Terashi

Authors
  1. F. Kashiwagi M. D.
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  2. Y. Katayama
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  3. H. Igarashi
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  4. S. Iida
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  5. H. Muramatsu
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  6. A. Terashi
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red-Cross Hospital, Tokyo, Japan

    Umeo Ito M.D. (Director and Neurosurgeon in Chief) (Director and Neurosurgeon in Chief)

  2. Institut für Chirurgische Forschung, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Alexander Baethmann M.D. (Professor) (Professor)

  3. Max-Planck Institut für Neurologische Forschung, Köln, Federal Republic of Germany

    Konstantin-A. Hossmann M.D. (Professor) (Professor)

  4. Department of Neuropathology, Tokyo Medical and Dental University, Tokyo, Japan

    Toshihiko Kuroiwa M.D. (Associate Professor) (Associate Professor)

  5. Division of Neurosurgery, Medical College of Virginia, Richmond, Virginia, USA

    Anthony Marmarou Ph.D. (Professor) (Professor)

  6. Neurochirurgische Klinik, Ludwig-Maximilians-Universität, München, Federal Republic of Germany

    Hans-J. Reulen M.D. (Professor) (Professor)

  7. Department of Neurosurgery, Tokyo Women’s Medical College, Tokyo, Japan

    Kintomo Takakura M.D. (Professor) (Professor)

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© 1994 Springer-Verlag

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Kashiwagi, F., Katayama, Y., Igarashi, H., Iida, S., Muramatsu, H., Terashi, A. (1994). Effect of a New Calcium Antagonist (SM-6586) on Experimental Cerebral Ischemia. In: Ito, U., et al. Brain Edema IX. Acta Neurochirurgica, vol 60. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9334-1_77

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  • DOI: https://doi.org/10.1007/978-3-7091-9334-1_77

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9336-5

  • Online ISBN: 978-3-7091-9334-1

  • eBook Packages: Springer Book Archive

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