Zusammenfassung
Unter dem Einfluß der beiden primären lymphatischen Organe, Thymus und Bursaäquivalent, erlangen die im Knochenmark gebildeten Stammzellen die Fähigkeit, sich zu zwei immunkompetenten Zellreihen zu differenzieren: Unter dem Einfluß des Thymus differenziert sich die lymphatische Stammzelle innerhalb des Thymus zum Thymozyten und besiedelt als T-Lymphozyt die Thymus-abhängigen Regionen von Milz und Lymphknoten. T-Lymphozyten sind durch bestimmte morphologische und funktionelle Merkmale gekennzeichnet und gelten als Träger der zellulären Immunität.
Preview
Unable to display preview. Download preview PDF.
Literatur
- Abe, K., Ito, T.: Fine structure of small lymphocytes in the thymus of the mouse: Qualitative and quantitative analysis by electron microscopy. 2. Zellforsch. 110, 321 (1970).Google Scholar
- Avrameas, S.: Coupling of enzymes to proteins with glutaraldehyde. Use of the conjugates for the detection of antigens and antibodies. Immunochemistry 6, 43 (1969).PubMedGoogle Scholar
- Avrameas, S.: Immunoenzyme techniques: Enzymes as markers for the localization of antigens and antibodies. Int. Rev. Cytol. 27, 349 (1970).PubMedGoogle Scholar
- Basten, A., Miller, J. F. A. P., Sprent, J., Pye, J.: A receptor for antibody on B lymphocytes. I. Method of detection and functional significance. J. exp. Med. 135, 610 (1972).Google Scholar
- Basten, A., Warner, N. L., Mandel, T.: A receptor for antibody on B lymphocytes. II. Immunochemical and electron microscopy characteristics. J. exp. Med. 135, 627 (1972).PubMedGoogle Scholar
- Basten, A., Miller, J. F. A. P., Warner, N. L., Abraham, R., Chia, E., Gamble, J.: A subpopulation of T cells bearing Fc receptors. J. Immunol. 115, 1159 (1975).PubMedGoogle Scholar
- Berkum, D. W. van, Noord, M. J. van, Maat, B., Dicke, K. A.: Attempts at identification of hemopoietic stem cell in mouse. Blood 38, 547 (1971).Google Scholar
- Bentwich, Z., Douglas, S. D., Siegal, F. P., Kunkel, H. G.: Human lymphocyte-sheep erythrocyte rosette formation: Some characteristics of the interaction. Clin. Immunol. Immunopath. 1, 511 (1973).Google Scholar
- Bentwich, Z., Kunkel, H. G.: Specific properties of human B and T lymphocytes and alterations in disease. Transplant. Rev. 16, 29 (1973).PubMedGoogle Scholar
- Bianco, C., Patrick, R., Nussenzweig, V.: A population of lymphocytes bearing a membrane receptor for antigen-antibody-complement complexes. I. Separation and characterization. J. exp. Med. 132, 702 (1970).Google Scholar
- Biberfeld, P.: Endocytosis and lysosome formation in blood lymphocytes transformed by phytohemagglutinin. J. Ultrastruct. Res. 37, 41 (1971).PubMedGoogle Scholar
- Bobrove, A. M., Strober, S., Herzenberg, L. A., De Pamphilis, J. D.: Identification and quantitation of thymus-derived lymphocytes in human peripheral blood. J. Immunol. 112, 520 (1974).PubMedGoogle Scholar
- Brittinger, G., Hirschhorn, R., Douglas, S. D., Weissmann, G.: Studies on lysosomes. XI. Characterization of a hydrolase-rich fraction from human lymphocytes. J. Cell Biol. 37, 394 (1968).PubMedGoogle Scholar
- Brooks, R. E., Siegel, B. V.: Normal human lymph node cells: An electron microscopic study. Blood 27, 687 (1966).PubMedGoogle Scholar
- Brown, G., Greaves, M. F.: Cell surface markers for human T and B lymphocytes. Europ. J. Immunol. 4, 302 (1974).Google Scholar
- Brunning, R. D., Parkin, J.: Ultrastructural studies of parallel tubular arrays in human lymphocytes. Amer. J. Path. 78, 59 (1975).PubMedGoogle Scholar
- Burke, J. S., Simon, G. T.: Electron microscopy of the spleen. I. Anatomy and micro-circulation. Amer. J. Path. 58, 127 (1970).Google Scholar
- Campbell, F. R.: Ultrastructural studies of transmural migration of blood cells in the bone marrow of rats, mice and guinea pigs. Amer. J. Anat. 135, 521 (1972).PubMedGoogle Scholar
- Carr, I.: The fine structure of the mammalian lymphoreticular system. Int. Rev. Cytol. 27, 283 (1970).PubMedGoogle Scholar
- Chakravarty, A., Kubai, L., Sidky, Y., Auerbach, R.: Ontogeny of thymus cell function. Ann. N. Y. Acad. Sci. 249, 34 (1975).PubMedGoogle Scholar
- Clark, S. L.: The thymus in mice of strain 129/J, studied with the electron microscope. Amer. J. Anat. 112, 1 (1963).PubMedGoogle Scholar
- Clark, S. L.: The synthesis and storage of protein by isolated lymphoid cells, examined by autoradiography with the electron microscope. Amer. J. Anat. 119, 375 (1966).PubMedGoogle Scholar
- Cohnen, G.: T- und B-Lymphozyten bei chronischer lymphatischer Leukämie und Lymphogranulomatose. Stuttgart: G. Fischer, 1975.Google Scholar
- De Bryn, P. P. H., Michelson, S., Thomas, T. B.: The migration of blood cells of the bone marrow through the sinusoidal wall. J. Morph. 133, 417 (1971).Google Scholar
- Dicke, K. A., Noord, M. J. van, Maat, B., Schaefer, U. W., Bekkum, D. W. van: Identification of cells in primate bone marrow resembling the hemopoietic stem cell in the mouse. Blood 42, 195 (1973).PubMedGoogle Scholar
- Dickler, H. B., Adkinson, N. F. Jun., Terry, W. D.: Evidence for individual human peripheral blood lymphocytes bearing both B and T cell markers. Nature 247, 213 (1974).PubMedGoogle Scholar
- Douglas, S. D., Cohnen, G., Brittinger, G.: Ultrastructural comparison between phytomitogen transformed normal and chronic lymphocytic leukemia lymphocytes. J. Ultrastruct. Res. 44, 11 (1973).PubMedGoogle Scholar
- Elves, M. E.: The lymphocytes. London: Lloyd-Luke, 1972.Google Scholar
- Friess, A. E., Liebich, H.-G.: Ultrahistochemische Untersuchungen an der Glykokalyx von Lymphozyten aus dem Ductus thoracicus der Ratte. Z. Zellforsch. 134, 143 (1972).PubMedGoogle Scholar
- Frøland, S. S., Natvig, J. B.: Identification of three different human lymphocyte populations by surface markers. Transplant. Rev. 16, 114 (1973).PubMedGoogle Scholar
- Fukuda, T.: Undifferentiated mononuclear cell in human embryonic liver; presumptive hematopoietic stem cell. Virchows Arch., Abt. B, Zellpath. 14, 31 (1973).Google Scholar
- Gowans, J. L., Knight, E. J.: The route of recirculation of lymphocytes in the rat. Proc. roy. Soc. B. 159, 257 (1964).Google Scholar
- Grey, H. M., Kubo, R. T., Cerottini, J.-C: Thymus-derived (T) cell immunoglobulins. Presence of a receptor site for IgG and absence of large amounts of “buried” Ig determinants on T cells. J. exp. Med. 136, 1323 (1972).PubMedGoogle Scholar
- Haelst, U. van: Light and electron microscopic study of the normal and pathological Thymus of the rat. Z. Zellforsch. 80, 153 (1967).PubMedGoogle Scholar
- Hebel, R., Liebich, H.-G.: Elektronenmikroskopische Untersuchungen an kleinen Lymphozyten aus dem Ductus thoracicus der Ratte. Z. Zellforsch. 93, 232 (1969).PubMedGoogle Scholar
- Heiniger, H. J., Riedwyl, H., Giger, H., Sordat, B., Cottier, H.: Ultrastructural differences between thymic and lymph node small lymphocytes of mice: Nucleolar size and cytoplasmic volume. Blood 30, 288 (1967).PubMedGoogle Scholar
- Hovig, T., Jeremic, M., Stavem, P.: A new type of inclusion bodies in lymphocytes. Scand. J. Haemat. 5, 81 (1968).PubMedGoogle Scholar
- Huber, H., Michlmayr, G., Asamer, H., Huber, Ch., Braunsteiner, H.: Die Differenzierung menschlicher Blutlymphocyten mit immunologischen und autoradiographischen Methoden. I. Ergebnisse bei Normalpersonen und bei Patienten mit chronischer Lymphadenose. Klin. Wschr. 50, 504 (1972).PubMedGoogle Scholar
- Hudson, G., Yoffey, J. M.: The passage of lymphocytes through the sinusoidal endothelium of guinea-pig bone marrow. Proc. roy. Soc. B 165, 486 (1966).Google Scholar
- Huhn, D.: Über das Ergastoplasma von Lymphozyten des peripheren Blutes. Dtsch. med. Wschr. 93, 355 (1968).PubMedGoogle Scholar
- Huhn, D.: Neue Organelle im peripheren Lymphozyten; Dtsch. med. Wschr. 93, 2099 (1968).PubMedGoogle Scholar
- Huhn, D., Stich, W.: Fine structure of blood and bone marrow. An introduction to electron microscopic hematology. München: J. F. Lehmann, 1969.Google Scholar
- Huhn, D., Asamer, H.: Neuartige Einschlüsse im Ergastoplasma peripherer Lymphozyten bei Virusinfekt. Acta haemat. (Basel) 50, 245 (1973).Google Scholar
- Huhn, D., Rodt, H., Thierfelder, S.: Immunhistochemische Untersuchungen an T-lymphozyten der Maus. Blut 28, 415 (1974).PubMedGoogle Scholar
- Huhn, D., Rodt, H., Thierfelder, S.: Immunhistochemische Untersuchungen an Lymphozyten der Maus. Markierung mit Anti-B-Zell- und Anti-T-Zell-Globulin. Blut 29, 332 (1974).PubMedGoogle Scholar
- Huhn, D., Thiel, E., Rodt, H.: Immunoglobulin-Ablagerungen in Lymphadenose-Zellen. Klin. Wschr. 53, 317 (1975).PubMedGoogle Scholar
- Huhn, D., Rodt, H., Thiel, E., Fink, U., Ruppelt, W.: Elektronenmikroskopische immunhistochemische Untersuchungen an menschlichen Lymphozyten. Blut 32, 87 (1976).PubMedGoogle Scholar
- Hummeler, K., Harris, T. N., Harris, S., Farber, M. B.: Studies on antibody-producing cells. IV. Ultrastructure of plaque-forming cells of rabbit lymph. J. exp. Med. 135, 491 (1972).PubMedGoogle Scholar
- Hunt, S. V., Williams, A. F.: The origin of cell surface immunoglobulin of marrow-derived and thymus-derived lymphocytes of the rat. J. exp. Med. 139, 479 (1974).PubMedGoogle Scholar
- Jondal, M., Hohn, G., Wigzell, H.: Surface markers on human T- and B-lymphocytes. I. A large population of lymphocytes forming non-immune rosettes with sheep blood cells. J. exp. Med. 136, 207 (1972).Google Scholar
- Kahn, P., Plementas, H.: Die unspezifische Esteraseaktivität in menschlichen Lymphozyten. In: Der Lymphozyt, S. 53. Wien: Wiener Med. Akad., 1972.Google Scholar
- Kotani, M., Nawa, Y., Fujii, H., Fukumoto, R., Miyamoto, M., Yamashita, A.: Post-capillary venules as the pathway for migrating B lymphocytes. Cell Tissue Res. 152, 67 (1974).Google Scholar
- Lennert, K., Stein, H., Kaiserling, E.: Cytological and functional criteria for the classi-fication of malignant lymphomata. Brit. J. Cancer 31, 29 (1975).Google Scholar
- Liebich, H.-G.: Elektronenmikroskopische Untersuchungen an kleinen Lymphocyten aus dem Ductus thoracicus des Menschen. Res. exp. Med. 159, 87 (1972).Google Scholar
- Lorbacher, P., Yam, L. T., Mitus, W. J.: Cytochemical demonstration of ß-glucuronidase activity in blood and bone marrow cells. J. Histochem. Cytochem. 15, 680 (1967).PubMedGoogle Scholar
- Lukes, R. J., Collins, R. D.: New approaches to the classification of the lymphomata. Brit. J. Cancer 31, 1 (1975).Google Scholar
- Mähr, G.: Untersuchungen zur Frage der Spezifität der Glykogenfärbung in den Leukozyten. Wien Z. inn. Med. 51, 411 (1970).PubMedGoogle Scholar
- Matter, A., Lisowska-Bernstein, B., Ryser, J. E., Lamelin, J.-P., Vassalli, P.: Mouse thymus-independent and thymus-derived lymphoid cells. II. Ultrastructural studies. J. exp. Med. 136, 1008 (1972).PubMedGoogle Scholar
- Miller, J. F. A. P.: The thymus and the immune system. Vox. Sang. 20, 481 (1971).PubMedGoogle Scholar
- Mills, B., Sen, L., Borella, L.: Reactivity of antihuman thymocyte serum with acute leukemic blasts. J. Immunol. 115, 1038 (1975).PubMedGoogle Scholar
- Moe, R. E.: Electron microscopic appearance of the parenchyma of lymph nodes. Amer. J. Anat. 114, 341 (1964).PubMedGoogle Scholar
- Moore, R. D., Mumaw, V. G., Schoenberg, M. D.: The structure of the spleen and its functional implications. Exp. molec. Path. 3, 31 (1964).Google Scholar
- Mori, Y., Lennert, K.: Electron microscopic atlas of lymph node cytology and pathology. Berlin-Heidelberg-New York: Springer, 1969.Google Scholar
- Mori, M., Ishii, Y., Onoe, T.: Studies on the germinal center I. Ultrastructural study of germinal centers in human lymph nodes with correspondence to the zonal differentiation. J. Reticuloendothel. Soc. 6, 140 (1969).PubMedGoogle Scholar
- Murray, R. G., Murray, A., Pizzo, A.: The fine structure of the thymocytes of young rats. Anat. Ree. 151, 17 (1965).Google Scholar
- Nopajaroonsri, Ch., Luk, Sh. C., Simon, G. T.: Ultrastructure of the normal lymph node. Amer. J. Path. 65, 1 (1971).PubMedGoogle Scholar
- Nossal, G. J. V., Ada, G. L.: Antigens, lymphoid cells, and the immune response. New York-London: Academic Press, 1971.Google Scholar
- Nowell, P. C., Hirsch, B. E., Fox, D. H., Wilson, D. G.: Evidence for the existence of multipotential lympho-hematopoietic stem cells in the adult rat. J. cell. Physiol. 75, 151 (1970).PubMedGoogle Scholar
- Osmond, D. G., Miller, S. C., Yoshida, Y.: Kinetic and haemopoietic properties of lymphoid cells in the bone marrow. In: Ciba foundation symposium 13 haemopoietic stem cells, p. 131. Amsterdam-London-New York: Elsevier Associated Scientific Publishers, 1973.Google Scholar
- Perlmann, P., Perlmann, H., Müller-Eberhard, H. J.: Cytolytic lymphocytic cells with complement receptor in human blood. Induction of cytolysis by IgG antibody but not by target cell-bound C 3. J. exp. Med. 141, 287 (1975).PubMedGoogle Scholar
- Pernis, B., Forni, L., Amante, L.: Immunoglobulins as cell receptors. Ann. N.Y. Acad. Sci. 190, 420 (1971).PubMedGoogle Scholar
- Pietschmann, H.: Zytochemie der Lymphozyten. In: Der Lymphozyt, S. 43. Wien: Wiener Med. Akad., 1972.Google Scholar
- Polliack, A., Lampen, N., Clarkson, B. D., Harven, E. De: Identification of human B and T lymphocytes by scanning electron microscopy. J. exp. Med. 138, 607 (1973).PubMedGoogle Scholar
- Rieber, E. P., Riethmüller, G.: Surface immunoglobulin on thymus cells. I. Increased immunogenicity of heterologus anti-Ig bound to thymus cells. Z. Immun-Forsch. 147, 262 (1974).Google Scholar
- Rodt, H., Thierfelder, S., Thiel, E., Götze, D., Netzel, B., Huhn, D., Eulitz, M.: Identification and quantitation of human T-cell antigen by antisera from antibodies cross-reacting with hemopoietic progenitors and other blood cells. Immunogenetics 2, 411 (1975).Google Scholar
- Rosenstreich, D. L., Shevach, E., Green, I., Rosenthal, A. S.: The uropod-bearing lymphocyte of the guinea pig. J. exp. Med. 135, 1937 (1972).Google Scholar
- Rosse, C.: Lymphocyte production and life-span in the bone marrow of the guinea pig. Blood 38, 372 (1971).PubMedGoogle Scholar
- Rubin, B., Hertel-Wulff, B.: Biological significance of Fc receptor-bearing cells among activated T lymphocytes. Scand. J. Immunol. 4, 451 (1975).PubMedGoogle Scholar
- Rubinstein, A. S., Trobaugh, F. E., Jr.: Ultrastructure of presumptive hematopoietic stem cells. Blood 42, 61 (1973).PubMedGoogle Scholar
- Ryser, J.-E., Vassalli, P.: Mouse bone marrow lymphocytes and their differentiation. J. Immunol. 113, 719 (1974).PubMedGoogle Scholar
- Sanel, F. Th.: Ultrastructure of differentiating cells during thymus histogenesis. A light and electron microscopic study of epithelial and lymphoid cell differentiation during thymus histogenesis in C 57 black mice. Z. Zellforsch. 83, 8 (1967).PubMedGoogle Scholar
- Sciler, F. R., Sedlacek, H. H., Kanzy, E. J., Lang, W., Über die Brauchbarkeit immunologischer Nachweismethoden zur Differenzierung funktionell verschiedener Lymphozyten: Spontanrosetten, Komplementrezeptor-Rosetten und Immunglobulinrezeptoren. Behring. Inst. Mitt. 52, 26 (1972).Google Scholar
- Sordat, B., Sordat, M., Hess, M. W., Stoner, R. D., Cottier, H.: Specific antibody within lymphoid germinal center cells of mice after primary immunization with horse radish peroxidase: A light and electron microscopic study. J. exp. Med. 131, 77 (1970).PubMedGoogle Scholar
- Steidle, Ch., Huhn, D.: Elektronenmikroskopische Untersuchungen zur Phagocytose von Blutlymphocyten. Res. exp. Med. 163, 155 (1974).Google Scholar
- Swartzendruber, D. C., Hanna, M. G.: Electron microscopic autoradiography of germinal center cells in mouse spleen. J. Cell. Biol. 25, 109 (1965).PubMedGoogle Scholar
- Tanaka, Y., Liddy, T. J.: Lipids and acid phosphatase in cultured lymphocytes of peripheral blood. Lab. Invest. 15, 455 (1966).PubMedGoogle Scholar
- Trepel, F.: Number and distribution of lymphocytes in man. A critical analysis. Klin. Wschr. 52, 511 (1974).PubMedGoogle Scholar
- Trepel, F., Schick, P.: Dynamik im lymphatischen Zellsystem. Med. Klin. 70, 581 (1975).PubMedGoogle Scholar
- Unanue, E. R., Grey, H. M., Rabellino, E., Campbell, P., Schmitke, J.: Immunoglobulins on the surface of lymphocytes. II. The bone marrow as the main source of lymphocytes with detectable surface-bound immunoglobulin. J. exp. Med. 133, 1188 (1971).PubMedGoogle Scholar
- Weiss, L.: Transmural cellular passage in vascular sinues of rat bone marrow. Blood 36, 189 (1970).PubMedGoogle Scholar
- Winchester, R. J., Fu, S. M., Hoffman, T., Kunkel, H. G.: IgG on lymphocyte surfaces; technical problems and the significance of a third cell population. J. Immunol. 114, 1210 (1975).PubMedGoogle Scholar
- Wivel, N. A., Mandel, M. A., Asofsky, R. M.: Ultrastructural study of thoracic duct lymphocytes of mice. Amer. J. Anat. 128, 57 (1970).PubMedGoogle Scholar
- Yoffey, J. M.: Stem cell role of the lymphocyte-transitional cell (LT) compartment. In: Ciba foundation symposium 13 haemopoietic stem cells, pp. 5. Amsterdam-London-New York: Elsevier Associated Scientific Publishers, 1973.Google Scholar
- Zucker-Franklin, D.: The ultrastructure of lymphocytes. Sem. Hemat. 6, 4 (1969).Google Scholar
- Zucker-Franklin, D.: The ultrastructure of cells in human thoracic duct lymph. J. Ultrastruct. Res. 9, 325 (1963).Google Scholar
Literatur
- Agliozzo, C. M., Reingold, I. M.: Infectious mononucleosis simulating Hodkin’s disease: A patient with Reed-Sternberg cells. Amer. J. clin. Path. 56, 730–735 (1971).Google Scholar
- Andre, R., Dreyfus, B., Bessis, M.: La ponction ganglionnaire dans la maladie de Hodgkin examinée au microscope électronique. Presse med. 63, 967–970 (1955).PubMedGoogle Scholar
- Azar, H. A.: Significance of the Reed-Sternberg cell. Human Path. 6, 479–484 (1975).Google Scholar
- Bernhard, W., Leplus, R.: Structure fine du ganglion humain normal et malin. Paris: Gauthier-Villars, 1964. Bessis, M.: Cellules du sang normal et pathologiques. Paris: Masson et Cie., 1972.Google Scholar
- Braunstein, H., Freiman, D. G., Thomas, W.: A histochemical study of the enzymatic activity of lymph nodes. III. Granulomatous and primary neoplastic conditions of lymphoid tissue. Cancer 15, 139–152 (1962).PubMedGoogle Scholar
- Braunsteiner, H., Fellinger, K., Pakesch, F.: Electron microscopic investigations on sections from lymph nodes and bone marrow in malignant blood disease. Blood 12, 278–294 (1957).PubMedGoogle Scholar
- Carr, I.: The macrophage. A review of ultrastructure and function. London: Academic Press, 1973.Google Scholar
- Carr, I.: Ultrastructure of malignant reticulum and Reed-Sternberg cells. Lancet I, 926 (1975).Google Scholar
- Dorfman, R. F.: Enzyme histochemistry of the cells in Hodkin’s disease and allied disorders. Nature 190, 925–926 (1961).PubMedGoogle Scholar
- Dorfman, R. F., Rice, D. F., Mitchell, A. D., Kempson, R. L., Levine, G.: Ultrastructural studies of Hodgkin’s disease. Nat. Cancer Inst. Monogr. 36, 221–238 (1973).PubMedGoogle Scholar
- Fleischhacker, H., Klima, R.: Zellbilder von Lymphknotenpunktaten und ihre diagnostische Verwertbarkeit. Münchner med. Wschr. 17, 661–664 (1937).Google Scholar
- Frajola, W. J., Greider, M. H., Bouroncle, B. A.: Cytology of the Sternberg-Reed cell as revealed by the electron microscope. Ann. N.Y. Acad. Sci. 73/1, 221 – 236 (1958).Google Scholar
- Gigante, D., Marotta, U., Tomassini, N.: Osservazioni al microscopio elettronico di lin-fonodi in condizioni normali e patologiche (leucemia linfoide cronica, granuloma maligno e linfosarcoma). Rend. dell’Ist. sup. di Sanità 24, 128–138 (1961).Google Scholar
- Kay, M. M. B., Kadin, M.: Surface characteristics of Hodgkin’s cells. Lancet I, 748–749 (1975).Google Scholar
- Krishan, A., Chaudhuri, R. R.: Asynchrony of nuclear development in cytochalasin induced multinucleate cells. J. Cell Biol. 43, 618–621 (1969).PubMedGoogle Scholar
- Langhans, Th.: Das maligne Lymphosarkom (Pseudoleukämie). Virchows Arch. 54, 509–537 (1872).Google Scholar
- Lennert, K.: Histologische Studien zur Lymphogranulomatose. I. Die Cytologie der Lymphogranulomzellen. Frankfurter Zschr. Path. 64, 209–234 (1953).Google Scholar
- Lukes, R. J., Butler, J. J.: The pathology and nomenclature of Hodgkin’s disease. Cancer Res. 26, 1063–1081 (1966).PubMedGoogle Scholar
- Lukes, R. J., Craver, L. F., Hall, T. C., Rappaport, H., Ruben, P.: Report of the nomenclature comittee. Cancer Res. 26, 1311 (1966).Google Scholar
- Lukes, R. J., Tindle, B. H., Parker, J. W.: Reed-Sternberg-like cells in infectious mononucleosis. Lancet II, 1003–1004 (1969).Google Scholar
- Medlar, E. M.: Interpretation of the nature of Hodgkin’s disease. Amer. J. Path. 7, 499–514 (1931).PubMedGoogle Scholar
- Moeschlin, S., Schwarz, E., Wang, H.: Die Hodgkin-Zellen als Tumorzellen. Schweiz. med. Wschr. 41, 1103–1112 (1950).Google Scholar
- Mori, Y., Lennert, K.,: Electron microscopic atlas of lymph node cytology and pathology. Berlin-Heidelberg-New York: Springer, 1969.Google Scholar
- Ogawa, K.: Elektronenoptische Untersuchungen bei einem Fall von sogenanntem Hodgkin-Sarkom. Frankfurter Zschr. Path. 71, 677–693 (1962).Google Scholar
- Parker, J. W., Wakasa, J., Lukes, R. J.: Cytoplasmic fibrils in mixed lymphocyte cultures. Blood 29, 608–615 (1967).PubMedGoogle Scholar
- Schaefer, H. E.: Ultrastruktur maligner Lymphome. Referat, Tagung der Deutschen und österreichischen Gesellschaft für Hämatologie, Bad Nauheim 1975; Blut, im Druck.Google Scholar
- Strum, S. B., Park, J. K., Rappaport, H.: Observations of cells resembling Sternberg-Reed cells in conditions other than Hodgkin’s disease. Cancer 26, 176–190 (1970).PubMedGoogle Scholar
- Thomson, A. D.: The thymic origin of Hodgkin’s disease. Brit. J. Cancer 9, 37–50 (1955).PubMedGoogle Scholar
- Tindle, B. H., Parker, J. W., Lukes, R. J.: “Reed-Sternberg cells” in infective mononucleosis? Amer. J. Clin. Path. 58, 607–617 (1972).Google Scholar
Literatur
- Aisenberg, A. C., Bloch, K. S., Long, J. C.: Cell-surface immunoglobulins in chronic lymphocytic leukemia and allied disorders. Amer. J. Med. 55, 184 (1973).PubMedGoogle Scholar
- Begemann, H.: Klinische Hàmatologie. Stuttgart: Georg Thieme, 1970.Google Scholar
- Bennett, M. H., Farrer-Brown, G., Henry, K., Jelliffe, A. M.: Classification of non Hodgkin’s lymphomas (Letters). Lancet II, 405 (1974).Google Scholar
- Bernard, J., Bessis, M., Soulier, J. P., Thiéry, J. P.: Étude au microscope électronique d’une leucémie lymphoide avec cristaux intra-cytoplasmique. Rev. Hémat. 14, 227 (1959).PubMedGoogle Scholar
- Bessis, M.: Étude au microscope électronique des leucocytes normaux et leucémiques. Acta Union int. Cancer 7, 646 (1951).Google Scholar
- Bessis, M.: Living blood cells and their ultrastructure. Berlin-Heidelberg-New York: Springer, 1973.Google Scholar
- Bessis, M., Thiéry, J. P.: Études au microscope électronique sur les leucémies humaines. II. Les leucémies lymphocytaires. Comparaison avec la leucémie de la souries de souche AK. Nouv. Rev. franc. Hémat. 2, 387 (1962).PubMedGoogle Scholar
- Boiron, M., Flandrin, G., Ripault, J., Lortholang, P., Teillet, F., Jacquillot, C, Bernard, J.: Histio-lymphocytose médullaire et splénique d’apparence primitive. Nouv. Rev. franc. d’Hémat. 8, 178 (1968).Google Scholar
- Borella, L., Sen, L., Green, A. A.: Cell surface markers and clinical features in acute lymphocytic leukemia (ALL). Proc. Amer. Ass. Cancer Res. 15, 122 (1974).Google Scholar
- Burke, J. S., Byrne, G. E., Rappaport, H.: Hairy cell leukaemia (leukaemic reticuloendo- theliosis). I.A. clinical pathologic study of 21 patients. Cancer 33, 1399 (1974).PubMedGoogle Scholar
- Burns, C. P., Hoak, J. C.: Freeze-etching, scanning and thin section electron microscopic studies of the “hairy” leukocytes in leukaemic reticuloendotheliosis. J. nat. Cancer Inst. 51, 743 (1973).PubMedGoogle Scholar
- Catovsky, D., Pettit, J. E., Galetto, J., Okos, A., Gatton, D. A. G.: The B-lymphocyte nature of the hairy cell of leukaemic reticuloendotheliosis. Brit. J. Haemat. 26, 29 (1974).PubMedGoogle Scholar
- Daniel, M. T., Flandrin, G.: Fine structure of abnormal cells in hairy cell (tricholeukocytic) leukaemia, with special reference to their in vitro phagocytic capacity. Lab. Invest. 30, 1 (1974).PubMedGoogle Scholar
- Diebold, J.: Classification morphologique des lymphoides non hodgkiniens. Nouv. Presse Médicale 3, 1818 (1974).Google Scholar
- Dorfman, R. F.: Classification of non Hodgkin’s lymphomas (Letter). Lancet I, 1295 (1974).Google Scholar
- Dorfman, R. F.: Classification of non-Hodgkin’s lymphomas (Letter). Lancet II, 961 (1974).Google Scholar
- Flandrin, G., Daniel, M. T., Fourcade, M., Chelloui, N.: Leucémies a tricholeucocyte: (Hairy cell leukaemia). Étude clinique et cytologique de 55 observations. Nouv. Rev. franc. d’Hémat. 13, 609 (1973).Google Scholar
- Gérard-Marchant, R., Hamlin, I., Lennert, K., Rilke, F., Stansfeld, A. G., Unnik, J. A. M. van: Classification of non-Hodgkin’s lymphomas (Letter). Lancet II, 406 (1974).Google Scholar
- Golomb, H. M., Braylan, R., Polliack, A.: “Hairy” cell leukaemia (Leukaemic reticulo-endotheliosis): a scanning electron microscopic study of eight cases. Brit. J. Haemat. 29, 455 (1975).PubMedGoogle Scholar
- Ghadially, F. N., Skinnider, L. F.: Ultrastructure of hairy cell leukemia. Cancer 29, 444 (1972).PubMedGoogle Scholar
- Huhn, D.: Feinstruktur peripherer Lymphocyten bei chronischer lymphatischer Leukämie. Dtsch. med. Wschr. 95, 897 (1970).PubMedGoogle Scholar
- Huhn, D., Schmalzl, F.: Licht- und elektronenmikroskopische Cytochemie der unreifzelligen Leukämien. Klin. Wschr. 50, 423–433 (1972).PubMedGoogle Scholar
- Huhn, D., Thiel, E., Rodt, H.: Immunglobulinablagerungen in Lymphadenosezellen. Klin. Wschr. 53, 317 (1975).PubMedGoogle Scholar
- Huhn, D., Rodt, H., Thiel, E., Fink, U., Ruppelt, W.: Elektronenmikroskopische immun- histochemische Untersuchungen an menschlichen Lymphozyten. Im Druck.Google Scholar
- Jaffe, E. S., Shevach, E. M., Frank, M. M., Berard, C. W., Green, J.: Nodular lymphoma-evidence for origin from follicular B lymphocytes. New Engl. J. Med. 290, 813 (1974).PubMedGoogle Scholar
- Katayama, I., Li, C. Y., Yam, L. T.: Histochemical study of acid phosphatase isoenzyme in leukaemic reticuloendotheliosis. Cancer 29, 157 (1972).PubMedGoogle Scholar
- Leder, L. D.: Der Nachweis der Naphthol-AS-D-Chloracetat-Esterase und Scine Bedeutung für die histologische Diagnostik. Verh. dtsch. path. Ges. 48, 317 (1974).Google Scholar
- Lennert, K.: Classification of malignant lymphomas (European concept). In: Progress in lymphology (ed. Rüttimann, A. ). Stuttgart: Georg Thieme, 1967.Google Scholar
- Lennert, K.: Follicular lymphoma: a special entity of malignant lymphomas. 1. Meeting European Division of the International Society of Haematology, Milano, 1971.Google Scholar
- Lennert, K.: Data presented at the Lymphoma-meeting. Chicago, June 1973.Google Scholar
- Lennert, K.: Follicular lymphoma. A tumor of the germinal centers. In: Malignant diseases of the hematopoietic system (eds. Akazaki, K., Rappaport, J., Berard, C. W., Benett, J. M., Ishikawa, E.). University of Tokyo Press, 1973.Google Scholar
- Lennert, K., Mohri, N.: Zur Pathologie der Leukämien und malignen Lymphome im Kin¬desalter (Referat). Verh. dtsch. path. Ges. 55, 216 (1971).Google Scholar
- Lennert, K., Stein, H., Kaiserling, E.: Cytological and functional criteria for the classi-fication of malignant lymphomata. Symposium on Non-Hodgkin’s Lymphomata. Brit. J. Cancer (Lond.) 31, Suppl. II, 29 (1975).Google Scholar
- Lennert, K., Mohri, N., Stein, H., Kaiserling, E.: The histopathology of malignant lymphoma. Brit. J. Haemat. 31, 193 (1975).Google Scholar
- Lukes, R. J., Collins, R. D.: New approaches to the classification of the lymphomata. Symposium on non-Hodgkin’s lymphomata. Brit. J. Cancer (Lond.) 31, Suppl. II, 1 (1975).Google Scholar
- Lutzner, M. A., Jordan, H. W.: The ultrastructure of an abnormal cell in Sezary’s syndrome. Blood 31, 719 (1963).Google Scholar
- Man, J. C. H. de, Meiners, W. B. H.: Crystals of protein nature in the cytoplasm of lymphatic cells in a case of lymphoreticular malignancy. Blood 20, 492 (1962).Google Scholar
- Mory, Y., Lennert, K.: Electron microscopic atlas of lymph node cytology and pathology. Berlin-Heidelberg-New York: Springer, 1969.Google Scholar
- Nieuwenhuis, P., Kenning, F. J.: Germinal centres and the origin of the B-cell system. II. Germinal centres in the rabbit spleen and popliteal lymph nodes. Immunology 26, 509 (1974).PubMedGoogle Scholar
- Polliack, A., Lampen, N., Clarkson, B. D., Harven, E. de, Bentwich, Z., Siegal, F. P., Kunkel, H. G.: Identification of human B and T lymphocytes by scanning electron microscopy. J. Exp. Med. 138, 607 (1973).PubMedGoogle Scholar
- Polliack, A., Lampen, N., Harven, E. de: Scanning electron microscopy of lymphocytes of known B and T derivation. In: Scanning Electron Microscopy 1974 (Part III, 673), 7th Annual Scanning Electron Microscope Symposium, Chicago (1974).Google Scholar
- Polliack, A., Harven, E. de: Surface features of normal and leukemic lymphocytes as seen by scanning electron microscopy. Clin.. Immunol, and Immunopathol. 3, 412 (1975).Google Scholar
- Rappaport, H.: Atlas of tumour pathology. Sect. 3 Fasc. 8: Tumours of the hematopoietic system. Washington D.C. AFIP, 1966.Google Scholar
- Robb-Smith, A. H. T.: The classification and natural history of the lymphadenopathies. Treatment of cancer and allied diseases, 2nd ed., Vol. 9: Lymphomas and releated diseases (eds. Pack, G. T., Ariel, J. M. ). New York: Hoeber Medical Division, Harper and Row, 1964.Google Scholar
- Rubin, A. D., Douglas, S. D., Chessin, L. N., Glade, P. R., Dameshek, W.: Chronik reticulolymphocytic leukemia: Reclassification of “leukaemic reticuloendotheliosis” through functional characterization of the circulating mononuclear cells. Amer. J. Med. 47, 149 (1969).PubMedGoogle Scholar
- Ruzicka, F., Fierkens, D., Stacher, A.: Morphologische Veränderungen normaler und leukämischer Lymphozyten durch ALS in vitro. In: Der Lymphozyt (Hrsg. Pietschmann, H. ). Wien: Wiener Med. Akad., 1972.Google Scholar
- Schmalzl, F., Huhn, D., Braunsteiner, H.: Cytochemistry and ultrastructure of acute lymphatic leukemia. Europ. Kongr. Hämatologie, Mailand, 1971.Google Scholar
- Sezary, A., Bouvrain, Y.: Erythrodermie avec presence de cellules monstrueuses dans le derme et le sang circulant. Bull. Soc. franc. Derm. Syph. 45, 254 (1938).Google Scholar
- Spiro, S., Galton, D. A. G., Wiltshaw, E., Lohmann, R. C.: Follicular lymphoma: a survey of 75 cases with special reference to the syndrome resembling chronic lymphocytic leukaemia. Symposium on Non-Hodgkin’s Lymphomata. Brit. J. Cancer (Lond.) 31, Suppl. II, 60 (1975).Google Scholar
- Stein, H., Kaiserling, E., Lennert, K.: Neue Gesichtspunkte zur Systematik maligner Lymphome auf dem Boden immunochemischer Analysen. In: Leukämien und maligne Lymphome (ed. Stacher, A.). München-Berlin-Wien: Urban und Schwarzenberg, 1972.Google Scholar
- Stein, H., Lennert, K., Parwaresch, M. R.: Malignant lymphomas of B-cell type. Lancet II, 855 (1972).Google Scholar
- Stein, H., Kaiserling, E., Lennert, K.: Evidence for B-cell origin of reticulum cell sarcoma. Virchows Archiv, Abt. A 364, 51 (1974).Google Scholar
- Tanaka, Y., Goodman, J. R.: Electron microscopy of human blood cells. New York: Harper and Row, 1972.Google Scholar
- Trubowitz, S., Masek, B., Frasca, J. M.: Leukemic reticuloendotheliosis. Blood 38, 288 (1971).PubMedGoogle Scholar
- Yam, L. T., Li, C. Y., Lam, K. W.: Tartrate-resistant acid phosphatase isoenzyme in the reticulum cells of leukemic reticuloendotheliosis. New Engl. J. Med. 284, 357 (1971).Google Scholar
- Yam, L. T., Li, C. Y., Lam, K. W.: Tartrate-resistant acid phosphatase isoenzyme in the reticulum cells of leukemic reticuloendotheliosis. New Engl. J. Med. 284, 357 (1971).PubMedGoogle Scholar
Copyright information
© Springer-Verlag/Wien 1976