Novel Understanding on Thoracic Aortic Diseases from Bioengineering Concepts

  • T. M. J. van Bakel
  • F. J. H. Nauta
  • Michele Conti
  • Rodrigo Romarowski
  • Simone Morganti
  • J. A. van Herwaarden
  • C. Alberto Figueroa
  • F. Auricchio
  • Santi TrimarchiEmail author


Endovascular treatment modalities have decreased the mortality and morbidity of thoracic aortic diseases considerably in the past decades, due to the effectiveness of such interventions and the minimal invasive character. While endovascular treatment options have become more advanced, preoperative planning and follow-up outcomes are still mainly based on the measurement of the maximum diameter and growth rate of the thoracic aorta on static imaging. These measurements do not take into account the biomechanical aortic behavior over the cardiac cycle and do not visualize hemodynamic changes in blood flow.

In this chapter, we evaluate endovascular treatment options from a biomechanical point of view and assess how dynamic imaging and computational modeling may contribute to the understanding of thoracic aortic diseases and aid clinical decision-making.


Bioengineering Computational fluid dynamics Finite element analysis Thoracic aorta Aortic dissection Thoracic aortic aneurysm TEVAR 


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Copyright information

© Springer-Verlag GmbH Austria, part of Springer Nature 2019

Authors and Affiliations

  • T. M. J. van Bakel
    • 1
  • F. J. H. Nauta
    • 1
  • Michele Conti
    • 2
  • Rodrigo Romarowski
    • 2
  • Simone Morganti
    • 3
  • J. A. van Herwaarden
    • 4
  • C. Alberto Figueroa
    • 6
  • F. Auricchio
    • 2
  • Santi Trimarchi
    • 1
    • 5
    Email author
  1. 1.Thoracic Aortic Research Center, Policlinico San Donato IRCCSUniversity of MilanMilanItaly
  2. 2.Department of Civil Engineering and ArchitectureUniversity of PaviaPaviaItaly
  3. 3.Department of Electrical, Computer, and Biomedical EngineeringUniversity of PaviaPaviaItaly
  4. 4.Department of Vascular SurgeryUniversity Medical Center UtrechtUtrechtThe Netherlands
  5. 5.Department of Vascular SurgeryUniversity of MilanMilanItaly
  6. 6.Departments of Surgery and Biomedical EngineeringUniversity of MichiganAnn ArborUSA

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