Molecular Pathways and Animal Models of Coronary Artery Anomalies

Abstract

The coronary vascular system is a sophisticated, highly patterned anatomical entity, and therefore a wide range of congenital malformations of the coronary vasculature has been described. Despite the clinical interest of congenital coronary artery anomalies (CCA), very few attempts have been made to relate specific embryonic developmental mechanisms to the congenital anomalies of these blood vessels. This is so because developmental data about the morphogenesis of the coronary vascular system is derived from complex studies carried out in animals (mostly transgenic mice) and may not be noted by the clinicians who take the care of these patients. We will try to offer embryological explanations for a variety of CCA based on the analysis of multiple animal models for the study of cardiac embryogenesis, and suggest to the reader developmental mechanistic explanations for the pathogenesis of these anomalies.

Keywords

Coronary artery anomalies CAA Coronary vascular system Embryogenesis Coronary arteries Coronary veins Endothelium Classification Neural crest cells NCC Persistent truncus arteriosus PTA Hes1 Pax3 Pbx1 Tbx1 Epithelial-to-mesenchymal transition EMT Epicardial-derived cells EPDCs TGFβ TGFBR1 Fibroblast growth factor Vangl2 Vcam1 BMP2 Endocardial cells Outflow tract Endocardial cushions 

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Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  1. 1.Department of Animal Biology, Faculty of SciencesUniversity of MálagaMálagaSpain
  2. 2.Andalusian Center for Nanomedicine and Biotechnology (BIONAND)Campanillas (Málaga)Spain
  3. 3.Instituto de Biomedicina de Málaga (IBIMA)-Hospital Carlos de HayaMálagaSpain

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