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MicroRNA Regulation of Angiogenesis

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Angiogenesis and Vascularisation

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Abstract

Angiogenesis is a key biological response regulating embryonic development, tissue repair, tumor growth, and metastasis. It requires complex regulation of gene expression in a temporal-spatial manner. microRNAs (miRs) are 18–24 nucleotide-containing endogenous RNAs that exert substantial gene regulatory effects via a posttranscriptional mechanism. Recent advance in basic research revealed that miRs exert potent angiogenic control via direct targeting certain critical secretory factors and transcription factors in a cell autonomous and non-cell autonomous manner. This chapter comprehensively summarizes the current understanding in miR regulation of angiogenesis during embryonic stage, tissue injury, as well as tumorigenesis. Approaches to deliver anti-miR entity have been successfully developed in silencing miR level in vivo. miR-based therapy might provide specific and effective solution for managing ischemic diseases or controlling tumor growth and metastasis.

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Acknowledgements

This work was supported by National Institute of Health Grants GM 069589 and GM 077185 to C.K.S.

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  1. Department of Surgery, Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 473 West 12th Avenue, Columbus, OH, 43210, USA

    Chandan K. Sen & Yuk Cheung Cyrus Chan

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  1. Chandan K. Sen
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  2. Yuk Cheung Cyrus Chan
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Correspondence to Chandan K. Sen .

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Editors and Affiliations

  1. Department of Medical Biotechnology, Jagiellonian University, Kraków, Poland, Kraków, Poland

    Józef Dulak

  2. Department of Medical Biotechnology, Jagiellonian University, Krakow, Poland, Krakow, Poland

    Alicja Józkowicz

  3. Department of Medical Biotechnology, Jagiellonian University, Kraków, Poland

    Agnieszka Łoboda

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Sen, C.K., Chan, Y.C.C. (2013). MicroRNA Regulation of Angiogenesis. In: Dulak, J., Józkowicz, A., Łoboda, A. (eds) Angiogenesis and Vascularisation. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1428-5_9

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