Trypanosoma

Chapter
First Online:

Abstract

This chapter describes the unique features of kinetoplastid molecular and cellular biology. Various adaptations, including antigenic variation and intracellular invasion, allow the parasites to survive in different environments within mammalian and arthropod hosts. Some molecular features are so unique that they allow kinetoplastids to serve as biological model systems.

Keywords

Alternative Oxidase Expression Site Bloodstream Form Variant Surface Glycoprotein Polypyrimidine Tract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

Notes

Further Reading

  1. Barrett MP, Croft SL (2012) Management of trypanosomiasis and leishmaniasis. Br Med Bull 104:175–196CrossRefPubMedPubMedCentralGoogle Scholar
  2. Bringaud F, Riviere L, Coustou V (2006) Energy metabolism of trypanosomatids: adaptation to available carbon sources. Mol Biochem Parasitol 149:1–9CrossRefPubMedGoogle Scholar
  3. DoCampo R, Jimenez V, Lander N, Li ZH, Niyogi S (2013) New insights into the roles of acidocalcisomes and the contractile vacuole complex in osmoregulation in protists. Int Rev Cell Mol Biol 305:69–113CrossRefPubMedGoogle Scholar
  4. Fernandes MC, Andrews NW (2012) Host cell invasion by Trypanosoma cruzi: a unique strategy that promotes persistence. FEMS Microbiol Rev 36:734–747CrossRefPubMedPubMedCentralGoogle Scholar
  5. Franco JR, Simarro PP, Diarra A, Jannin JG (2014) Epidemiology of human African trypanosomiasis. Clin Epidemiol 6:257–275PubMedPubMedCentralGoogle Scholar
  6. Goringer HU (2012) ‘Gestalt’, composition and function of the Trypanosoma brucei editosome. Annu Rev Microbiol 66:65–82CrossRefPubMedGoogle Scholar
  7. Horn D (2014) Antigenic variation in African trypanosomes. Mol Biochem Parasitol 195:123–129CrossRefPubMedPubMedCentralGoogle Scholar
  8. Kolev NG, Ullu E, Tschudi C (2014) The emerging role of RNA-binding proteins in the life cycle of Trypanosoma brucei. Cell Microbiol 16:482–489CrossRefPubMedPubMedCentralGoogle Scholar
  9. Krauth-Siegel R, Comini M (2008) Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism. Biochim Biophys Acta 1780:1236–1248CrossRefPubMedGoogle Scholar
  10. Langousis G, Hill KL (2014) Motility and more: the flagellum of Trypanosoma brucei. Nat Rev Microbiol 12:505–518CrossRefPubMedPubMedCentralGoogle Scholar
  11. Manna PT, Boehm C, Leung KF, Natesan SK, Field MC (2014) Life and times: synthesis, trafficking, and evolution of VSG. Trends Parasitol 30:251–258CrossRefPubMedPubMedCentralGoogle Scholar
  12. Osorio L, Rios I, Gutierrez B, Gonzalez J (2012) Virulence factors of Trypanosoma cruzi: who is who? Microbes Infect 14:1390–1402CrossRefPubMedGoogle Scholar
  13. Povelones ML (2014) Beyond replication: division and segregation of mitochondrial DNA in kinetoplastids. Mol Biochem Parasitol 196:53–60CrossRefPubMedGoogle Scholar
  14. Rassi A Jr, Rassi A, Marin-Neto JA (2010) Chagas disease. Lancet 375:1388–1402CrossRefPubMedGoogle Scholar
  15. Tiengwe C, Marques CA, McCulloch R (2014) Nuclear DNA replication initiation in kinetoplastid parasites: new insights into an ancient process. Trends Parasitol 30:27–36CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Wien 2016

Authors and Affiliations

  1. 1.ZMBHHeidelbergGermany

Personalised recommendations