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Association Between ICP Pulse Waveform Morphology and ICP B Waves

  • Magdalena Kasprowicz
  • Marvin Bergsneider
  • Marek Czosnyka
  • Xiao HuEmail author
Chapter
Part of the Acta Neurochirurgica Supplementum book series (NEUROCHIRURGICA, volume 114)

Abstract

The study aimed to investigate changes in the shape of ICP pulses associated with different patterns of the ICP slow waves (0.5–2.0 cycles/min) during ICP overnight monitoring in hydrocephalus. Four patterns of ICP slow waves were characterized in 44 overnight ICP recordings (no waves – NW, slow symmetrical waves – SW, slow asymmetrical waves – AS, slow waves with plateau phase – PW). The morphological clustering and analysis of ICP pulse (MOCAIP) algorithm was utilized to calculate a set of metrics describing ICP pulse morphology based on the location of three sub-peaks in an ICP pulse: systolic peak (P1), tidal peak (P2) and dicrotic peak (P3). Step-wise discriminant analysis was applied to select the most characteristic morphological features to distinguish between different ICP slow waves. Based on relative changes in variability of amplitudes of P2 and P3 we were able to distinguish between the combined groups NW + SW and AS + PW (p < 0.000001). The AS pattern can be differentiated from PW based on respective changes in the mean curvature of P2 and P3 (p < 0.000001); however, none of the MOCAIP feature separates between NW and SW. The investigation of ICP pulse morphology associated with different ICP B waves may provide additional information for analysing recordings of overnight ICP.

Keywords

Intracranial pressure Waveform analysis Hydrocephalus 

Notes

Acknowledgement

The present work is partially supported by NINDS R21 awards NS055998, NS055045 and NS059797 and R01 awards NS054881 and NS066008. MK is supported by the Foundation for Polish Science.

Conflict of interest statement

We declare that we have no conflict of interest.

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Copyright information

© Springer-Verlag/Wien 2012

Authors and Affiliations

  • Magdalena Kasprowicz
    • 1
    • 2
  • Marvin Bergsneider
    • 1
    • 4
  • Marek Czosnyka
    • 3
  • Xiao Hu
    • 1
    • 4
    Email author
  1. 1.Neural Systems and Dynamics Laboratory, Department of NeurosurgeryThe David Geffen School of Medicine, University of CaliforniaLos AngelesUSA
  2. 2.Institute of Biomedical Engineering and InstrumentationWroclaw University of TechnologyWroclawPoland
  3. 3.Academic Neurosurgical UnitAddenbrooke’s HospitalCambridgeUK
  4. 4.Biomedical Engineering Graduate Program, Henry Samueli School of Engineering and Applied ScienceUniversity of CaliforniaLos AngelesUSA

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