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Evolution of Jak and Stat Proteins

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Abstract

In this article, we examine the evolution of Jak and Stat proteins, and of the Jak-Stat pathway. We first introduce the protein families involved and the signaling pathway in general. We then oppose the simply structured pathway in Drosophila melanogaster to the more complex situation in mammals. Furthermore, we compare the Jak-Stat system between mammals and teleost fishes. Finally, we move to the less well investigated roles of Stats in the worm Caenorhabditis elegans and the slime mold Dictyostelium discoideum. We also survey the distribution of Jaks and Stats among metazoans and other eukaryotes. Orthologs of Stats are widely distributed among metazoans and are also found in choanoflagellates and in slime molds. In contrast, Jaks seem to be confined to the bilaterians and are apparently absent in molluscs, round- and flatworms. This indicates that the Jak-Stat pathway evolved at the base of the bilaterians, but has been lost in some invertebrate groups.

Keywords

Phylogenetic Profile Transcriptional Activation Region Zebrafish Chromosome Slime Mold Dictyostelium Discoideum Eukaryotic Tree 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We would like to thank Mathias Müller, Thomas Decker, and Birgit Strobl for critically reading the manuscript and Nicole Leitner and again Birgit Strobl for help during various stages of the manuscript. The research of CV is supported by and PS is funded by the FWF SFB-F28. IE acknowledges funding by the Wiener Wissenschafts-, Forschungs- und Technologie Fonds (WWTF), and from the DFG priority program SPP 1174 Deep Metazoan Phylogeny [Grant HA 1628/9].

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Copyright information

© Springer-Verlag Wien 2012

Authors and Affiliations

  1. 1.University of Veterinary MedicineViennaAustria
  2. 2.Center for Integrative Bioinformatics Vienna, Max F. Perutz LaboratoriesUniversity of ViennaViennaAustria

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