STAT1 and STAT3 Transcription Factors in Inflammation-associated Colon Cancer
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Inflammation is a strong promoter of colorectal cancer formation. Colorectal tumor cells establish heterotypic interactions with inflammatory cells in the stroma that are important for tumor angiogenesis and invasiveness. Recent studies in genetically modified mice have identified transcription factors and signaling networks that are implicated in these heterotypic tumor-stroma interactions and modulate preconditions of tumor formation such as chronic inflammation. Here, tumor-promoting and tumor-adverse effects of cytokine-activated transcription factors STAT1 and STAT3 in inflammatory cells and colorectal cancer cells are discussed.
KeywordsAdenomatous Polyposis Coli Inflammatory Bowel Disease Patient Colon Cancer Cell Line Intestinal Tumor Intestinal Cancer
This work was supported by the Austrian Science Fund FWF grant SFB F28 (RE), GENAU “Austromouse” (RE) and Doktoratskolleg plus IAI (Inflammation and Immunity; RE).
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