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Temporal profile of experimental ischemic edema after threshold amount of insult to induce infarction — ultrastructure, gravimetry and Evans’ blue extravasation

  • Umeo ItoEmail author
  • T. Kuroiwa
  • S. Hanyu
  • Y. Hakamata
  • E. Kawakami
  • I. Nakano
  • K. Oyanagi
Conference paper
Part of the Acta Neurochirurgica Supplements book series (NEUROCHIRURGICA, volume 86)

Abstract

When a threshold amount of temporary ischemic insult to induce focal infarction was given to the unilateral cerebral hemisphere of gerbils, a small focal infarct surrounded by a wide penumbra developed in the rostral portion of the cerebral cortex. During the first 5 hours following recirculation, whole astrocytic cell bodies and processes in the ischemic hemisphere were swollen, with an increase in the number of glycogen granules and in number and size of mitochondria. This swelling was an active reaction of astrocytes for neuronal protection, scavenging potassium, glutamate, and other neuronal metabolic products, and for generating fuels-for neurons (cyto-reactive edema). This reactive astrocytic swelling continued in the penumbra, but some dead neurons were found disseminated among the surviving neurons. Whereas, at 12–48 hours, focal infarction developed in which all cell membranes lost their GibbsDonnan’s equilibrium due to energetic failure of their membranous Na+/K+ ATPase. This is the cytotoxic edema (cyto-necrotic edema). In the infarct focus, when pericapillary astrocytic end-feet were damaged, the capillary BBB was broken; and thus vasogenic edema was superimposed on the cytotoxic edema.

Keywords

Cerebral ischemia ischemic brain edema penumbra infarction cytotoxic edema vasogenic edema cyto-reactive edema cyto-necrotic edema disseminated selective neuronal necrosis (DSNN) glycogen granules astrocytic mitochondria extracellular space intracellular space 

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Copyright information

© Springer-Verlag Wien 2003

Authors and Affiliations

  • Umeo Ito
    • 1
    • 3
    Email author
  • T. Kuroiwa
    • 2
  • S. Hanyu
    • 3
  • Y. Hakamata
    • 3
  • E. Kawakami
    • 1
  • I. Nakano
    • 3
  • K. Oyanagi
    • 1
  1. 1.Department of NeuropathologyTokyo Metropolitan Institute for NeuroscienceTokyoJapan
  2. 2.Department of Neuropathology, Medical Research InstituteTokyo Medical and Dental UniversityTokyoJapan
  3. 3.Department of NeurologyJichi Medical SchoolTochigiJapan

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