International Symposium State of Prevention and Therapy in Human Arteriosclerosis and in Animal Models pp 73-80 | Cite as
The Reversibility of the Human Atherosclerotic Plaque
Chapter
Abstract
Abundant evidence is being presented at this symposium indicating that even advanced atherosclerotic lesions can be made to regress in experimental animals. Under appropriate conditions lipid can be removed; necrotic debris can disappear; collagen can be resorbed at least to some extent; even calcium deposits can be reduced in size. Also the excessive proliferative activity of the lesion smooth muscle cells (SMC) that characterizes the active lesion can be reduced to the level of the SMC in the normal media.
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References
- Aschoff, L. (1924): Lectures in Pathology, Chapter 6, Atherosclerosis, Lane Lecture, San Francisco, Hoeber, New York.Google Scholar
- Blankenhorn, D.: Evidence for regression/progression of atherosclerosis in man, Proceedings of the International Workshop Conference on Atherosclerosis, London, Ontario, in press.Google Scholar
- Buchwald, H., Moore, R. B., and Varco, R. L. (1974): Surgical treatment of hyperlipidemia, Circulation 49 (Suppl. 1), 1–37.CrossRefGoogle Scholar
- Eilersen, P., and Faber, M. (1960): The human aorta, Arch. Path. 70, 103.PubMedGoogle Scholar
- Juhl, S. (1957): Cancer and atherosclerosis, Acta Path. Micro. Scand. 41, 99.CrossRefGoogle Scholar
- Knight, L., Scheibel, R., Amplatz, K., Varco, R. L., and Buchwald, L. (1972): Radiographic appraisal of the Minnesota partial ileal bypass study, Surg. Forum 23, 141.PubMedGoogle Scholar
- Ost, C. R., and Stenson, S. (1964): Regression of atherosclerosis during nicotinic acid therapy, in Niacin Vascular Disorders and Hyperlipemia (Ed. by R. Altshul ), pp. 243–262, Charles C. Thomas, Springfield.Google Scholar
- Starzl, T. E., Chase, H. P., Putnam, C. W., Nora, J. J., Fennell, R. H., and Porter, K. A. (1974): Portacaval shunt in hyperlipidemia, Lancet 2, 1263.PubMedCrossRefGoogle Scholar
- Variainen, I., and Kanerva, K. (1947): Arteriosclerosis and wartime. Annales Medicinae Experimentalis et Biologiae Fenniae 36, 748.Google Scholar
- Wanscher, O., Clemmesen, J., and Nielsen, A. (1951): Negative correlation between atherosclerosis and carcinoma, Brit. J. Cancer 5, 172.PubMedCrossRefGoogle Scholar
- Wilens, S. L. (1947): Resorption of arterial atheromatic deposits in wasting disease, Am. J. Path. 23, 793.PubMedGoogle Scholar
- Zelis, R., Mason, D. T., Braunwald, E., and Levy, R. I. (1970): Effects of hyperlipoproteinemia and their treatment on the peripheral circulation, J. of Clin. Invest. 49, 1007.CrossRefGoogle Scholar
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